Chlorpromazine combined with cidofovir for treatment of a patient suffering from progressive multifocal leukoencephalopathy

Intervirology
Christoph PöhlmannJacques Rohayem

Abstract

We report on a stem cell-transplanted patient with B cell chronic lymphatic leukemia who presented with a subacute onset of focal neurological deficits, gait abnormalities, emotional lability and dementia. Progressive multifocal leukoencephalopathy was diagnosed by magnetic resonance imaging (MRI) of the brain and detection of JC virus genome in the cerebrospinal fluid. Cidofovir and the 5HT2A receptor antagonist chlorpromazine were subsequently administered. A follow-up MRI of the brain 2 weeks after initiation of the antiviral therapy displayed progress of the demyelination, and the patient died 3 months after onset of the neurological symptoms. This report highlights the need for the development of novel and potent strategies for treatment of progressive multifocal leukoencephalopathy.

References

Oct 1, 1996·Italian Journal of Neurological Sciences·S GentileM T Giordana
Mar 1, 1997·Antimicrobial Agents and Chemotherapy·G AndreiE De Clercq
Oct 3, 1998·Annals of Internal Medicine·E J AnaissieM J Keating
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Igor J KoralnikNorman L Letvin
May 8, 2002·American Journal of Hematology·Brynjar VidarssonPall T Onundarson
Jul 4, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hans H Hirsch
Sep 14, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K R RaiL Brettman
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Stuart J KnechtleHans W Sollinger
Oct 7, 2003·Oncogene·Krzysztof Reiss, Kamel Khalili
Nov 20, 2004·Science·Gwendolyn F ElphickWalter J Atwood
Mar 2, 2006·Arthritis and Rheumatism·Kenji ItohMorito Sumiya
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anton Y PelegDavid L Paterson

❮ Previous
Next ❯

Citations

Apr 20, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Leslie J Marshall, Eugene O Major
Jul 17, 2008·Current HIV/AIDS Reports·Elizabeth A Hartman, DeRen Huang
Sep 9, 2010·Antimicrobial Agents and Chemotherapy·Zhi-Gang JiangEugene O Major
Jun 21, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hans H HirschCeline Leboeuf
Sep 22, 2011·Reviews in Medical Virology·Eleonora TavazziKamel Khalili
Jun 6, 2013·Clinical & Developmental Immunology·Cillian F De Gascun, Michael J Carr
Mar 8, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Cai YuanShahram Mori
Sep 16, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Eric M L Williamson, Joseph R Berger
Mar 18, 2021·Reviews in Medical Virology·Zongsong WuHans H Hirsch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.