PMID: 9161877Mar 1, 1997Paper

Chlorpromazine inhibits concanavalin A-induced liver injury independently of cytokine modulation

Immunology Letters
K IkedaM Takeuchi

Abstract

We investigated the effect of chlorpromazine (CPZ) in a murine model of T-cell-dependent liver injury caused by concanavalin A (ConA). CPZ (3 and 10 mg/kg) treatment 1 h before ConA injection prevented liver injury. CPZ (3, 10 mg/kg) administered 1 h after a ConA injection was also hepatoprotective, whereas cyclosporin (CsA, 100 mg/kg) was active only when given before ConA. Under either condition, CsA but not CPZ prevented concurrent increases in splenic ornithine decarboxylase (ODC) activity, a putative index of T-cell proliferation/differentiation. CPZ down-regulated tumor necrosis factor-alpha (TNF-alpha) and up-regulated IL-10 in mice that then received ConA, whereas delayed administration of CPZ had no effect. These results suggest that CPZ prevented liver injury without affecting the proliferation/differentiation of T-cells. The dissociation of hepatoprotection by CPZ from cytokine modulation indicates that this drug intervenes in the adherence of T-cells or the death of hepatocytes in the ConA-model.

Citations

Mar 17, 1999·European Journal of Pharmacology·M XiangF Nicoletti
Feb 13, 2001·Journal of Psychiatric Research·T PollmächerD Hinze-Selch
Apr 4, 2006·Brain, Behavior, and Immunity·Lukasz DrzyzgaZbigniew S Herman
Aug 26, 1998·Japanese Journal of Pharmacology·T OkamotoK Hara

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