PMID: 3687936Dec 1, 1987Paper

Chlorpropamide overdose in renal failure: management with charcoal hemoperfusion

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
S M LudwigC Faiman

Abstract

A potentially lethal chlorpropamide overdose in a patient with chronic renal failure on long-term hemodialysis was treated by two courses of charcoal hemoperfusion. Hemoperfusion shortened the half-life clearance of the drug from a mean value of 93.6 to 3.4 hours. Calculation of the fractional extraction indicated that hemoperfusion reduced the body burden of the drug by 24% and 19% (mean values) during the first and second hours of treatment, respectively. We conclude that charcoal hemoperfusion should be considered a definitive therapeutic option in such cases.

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