PMID: 3687936Dec 1, 1987Paper

Chlorpropamide overdose in renal failure: management with charcoal hemoperfusion

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
S M LudwigC Faiman


A potentially lethal chlorpropamide overdose in a patient with chronic renal failure on long-term hemodialysis was treated by two courses of charcoal hemoperfusion. Hemoperfusion shortened the half-life clearance of the drug from a mean value of 93.6 to 3.4 hours. Calculation of the fractional extraction indicated that hemoperfusion reduced the body burden of the drug by 24% and 19% (mean values) during the first and second hours of treatment, respectively. We conclude that charcoal hemoperfusion should be considered a definitive therapeutic option in such cases.


Mar 3, 1977·The New England Journal of Medicine·S W Shen, R Bressler
Jan 4, 1975·British Medical Journal·J A ValeR Goulding
Jan 1, 1974·Clinical Toxicology·J A Forrest
Apr 11, 1968·Annals of the New York Academy of Sciences·J Black
Apr 15, 1971·The New England Journal of Medicine·J L RosenbaumC Boreyko
Jan 1, 1980·Annual Review of Medicine·H S Seltzer
Nov 1, 1980·Clinical Toxicology·J L RosenbaumC G Bolisay
Nov 1, 1980·Clinical Toxicology·A TraffordR Evans
Nov 1, 1981·Journal of Analytical Toxicology·R C MeatherallN Donen
Oct 1, 1981·Clinical Toxicology·C BismuthM Galliot
Mar 30, 1959·Annals of the New York Academy of Sciences·J M STOWERSR B HUNTER

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