Chlorpropham-induced splenotoxicity and its recovery in rats

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
T FujitaniM Yoneyama

Abstract

To determine the reversibility of hematological and pathological changes in spleen induced by sub-chronic administration of chlorpropham (CIPC), male F344 rats were given CIPC in the diet at 0, 600, 3000 or 15,000 ppm for 13 weeks (administration period) and then were given standard (0 ppm) diet for 10 weeks (recovery period). At 0, 1, 2, 4 or 10 weeks in the recovery period, 5 rats in each groups were examined for hematology and pathology. At the end of CIPC administration, dose-dependent and significant methemoglobinemia, anemia, splenomegaly and pathological lesions indicating hemolytic anemia were observed in all the treated groups. The hematological changes, congestion of red pulp, lymphoid atrophy, increased extramedullary hematopoiesis in spleen and hematopoietic cell hyperplasia in bone marrow were diminished during the 10 weeks recovery period. However, increased hemosiderin deposition and capsular fibrosis in spleen of the treated groups remained at the end of recovery period. The results indicated that hematological changes induced by sub-chronic administration of CIPC were reversible but hemosiderin deposition and fibrosis in spleen were not reversible in the recovery period examined, suggesting the significance of ...Continue Reading

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Citations

Sep 20, 2007·Journal of Occupational Medicine and Toxicology·Jinky Leilanie Del Prado-Lu
Jun 14, 2014·Journal of Photochemistry and Photobiology. B, Biology·Yu LiMo Tao
Aug 7, 2012·Environmental Toxicology·Ali S Al-SararMousa Al-Ghothemi
Aug 19, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Masatomo RokushimaJun Ishizaki

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