Chlorpyrifos-induced parkinsonian model in mice: Behavior, histopathology and biochemistry

Pesticide Biochemistry and Physiology
Haci Ahmet Deveci, Mahmut Karapehlivan

Abstract

The aim of this study was to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on Paraoxonase (PON1) activity, and levels of lipid profile, total sialic acid (TSA), total antioxidant capacity (TAC) and total oxidant capacity (TOC) in the plasma and brain tissue of mice with chlorpyrifos-ethyl (CPF)-induced Parkinson. In the study, 35 male Swiss albino mice were divided into 5 groups including equal number of mice as follows; intraperitoneal injection of saline for mice in control (C) group, subcutaneous injection of 80mg/kg CPF for CPF group, intraperitoneal injection of 10μmol/kg CAPE for CAPE group, subcutaneous injection of 80mg/kg CPF and intraperitoneal injection of 10μmol/kg CAPE for CPF+CAPE group and intraperitoneal injection of 10% ethanol diluted in physiological saline solution for 21days for ethanol (E) group. All the mice were fed with normal feed and tap water ad libitum. At the end of the study, PON1 activity, lipid profile (except for brain), and TSA, TAC and TOC levels in the plasma and brain tissue were analyzed. Tissue samples of brain substantia nigra were evaluated histopathologically. Levels of plasma TAC, high density lipoprotein (HDL) and PON1 activity were statistically lower in C...Continue Reading

Citations

Jul 1, 2018·Environmental Science and Pollution Research International·Laetitia PoirierEric Chabrière
Feb 3, 2021·Biomolecules·Marwa BalahaViviana di Giacomo
Mar 26, 2021·Neurotoxicity Research·Mohamed El-GamalAhmed A Moustafa
May 8, 2021·Reviews on Environmental Health·Tahereh FarkhondehSaeed Samarghandian

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