Chlorthalidone decreases platelet aggregation and vascular permeability and promotes angiogenesis

Hypertension
Ryan WoodmanWarren Lockette

Abstract

Variations in diuretic-mediated inhibition of carbonic anhydrase-dependent chloride transport in platelets and vascular smooth muscle could account for the contrasting efficacy of the thiazide and thiazide-like diuretics in reducing cardiovascular morbidity in patients with hypertension. We assessed platelet carbonic anhydrase activity and catecholamine-induced platelet aggregation in the presence of a thiazide and a "thiazide-like" inhibitor of the sodium-chloride cotransporter. Individual variation in platelet carbonic anhydrase activity correlated with contrasting sensitivity to epinephrine-mediated platelet aggregation. Both chlorthalidone, which potently inhibits platelet carbonic anhydrase, and bendroflumethiazide, which has much less effect on this enzyme, increased the amount of epinephrine needed to induce platelet aggregation when compared with the absence of a diuretic. However, chlorthalidone was significantly more effective than bendroflumethiazide in reducing epinephrine-mediated platelet aggregation. Chlorthalidone also induced marked changes in the number of gene transcripts for two proteins that mediate angiogenesis and vascular permeability, vascular endothelial growth factor C and transforming growth factor-b...Continue Reading

References

Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K BeaumontD D Fanestil
Jan 6, 1994·The New England Journal of Medicine·P E RayP E Klotman
Jan 1, 1996·Journal of Cardiovascular Pharmacology and Therapeutics·K KomatsuE D Frohlich
Jun 6, 2000·American Journal of Respiratory Cell and Molecular Biology·R J KanerR G Crystal
Feb 13, 2001·British Journal of Pharmacology·P PickkersP Smits
Mar 30, 2001·The Journal of Biological Chemistry·Y MaeshimaR Kalluri
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Seiji TakashimaMasatsugu Hori
Jun 21, 2002·American Journal of Hypertension·Henrikas VaitkeviciusWarren Lockette
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Jun 25, 2005·Seminars in Cancer Biology·Hynda K Kleinman, George R Martin
Sep 29, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ryszard GrendaUNKNOWN ESCAPE Trial group
Oct 12, 2007·Kidney International·S ReungjuiR J Johnson
Nov 16, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Patrizia FerroniFiorella Guadagni
Apr 2, 2008·The New England Journal of Medicine·Nigel S BeckettUNKNOWN HYVET Study Group
Jun 24, 2008·Blood Pressure·Sverre E KjeldsenThomas Hedner
Oct 28, 2008·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Fumitaka IkomiToshio Ohhashi
Nov 11, 2008·Nature·Joshua I GreenbergDavid A Cheresh
Nov 13, 2008·Journal of Cardiovascular Medicine·Ugo TestaGian Luigi Condorelli
Dec 5, 2008·The New England Journal of Medicine·Kenneth JamersonUNKNOWN ACCOMPLISH Trial Investigators
Dec 5, 2008·The New England Journal of Medicine·Aram V Chobanian
Oct 16, 2009·American Journal of Physiology. Renal Physiology·Janina Müller-DeileMario Schiffer
Mar 20, 1942·The Journal of General Physiology·M H Jacobs, D R Stewart

❮ Previous
Next ❯

Citations

Jul 11, 2013·Current Hypertension Reports·George C RoushTheodore R Holford
Oct 5, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Beom-June KwonJae-Hyung Kim
Jul 4, 2012·Drugs·Vasiliki V GeorgiopoulouJaved Butler
Jan 22, 2014·Expert Opinion on Pharmacotherapy·Juan TamargoLuis M Ruilope
Dec 18, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Suzanne OparilFrank A Lederle
Nov 20, 2015·European Journal of Clinical Investigation·Chin-Chou HuangJaw-Wen Chen
Nov 22, 2011·Seminars in Nephrology·Michael E Ernst, Samuel J Mann
Oct 4, 2011·The American Journal of Medicine·Franz H Messerli, Sripal Bangalore
May 10, 2011·The American Journal of Cardiology·Hanna B SlimPaul D Thompson
Dec 7, 2011·The Journal of Clinical Hypertension·Clive Rosendorff
Sep 6, 2012·The Journal of Clinical Hypertension·Brian C Lund, Michael E Ernst
Jun 8, 2015·Current Opinion in Cardiology·Wanpen Vongpatanasin
Feb 9, 2012·Postgraduate Medicine·David S KountzMayer Ezer
Dec 9, 2014·The American Journal of Medicine·Edgar ArgulianFranz H Messerli
Mar 12, 2015·Future Cardiology·James J DiNicolantonioJames H O'Keefe
Jul 14, 2010·Hypertension·Theodore W Kurtz
Mar 7, 2018·Clinical Hypertension·Ravi Tejraj MehtaIndranil Purkait
Mar 19, 2019·Journal of Hypertension·Michel BurnierBryan Williams
Oct 9, 2019·Journal of Human Hypertension·Stela DinevaToni Vekov
Nov 6, 2015·American Journal of Physiology. Renal Physiology·Simone Costa Alarcon AriasRoberto Zatz
Jul 28, 2018·BioMed Research International·Maciej JakubowskiAdrian Doroszko
Apr 4, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Hafiz Muhammad Abdur RahmanImran Imran
Nov 2, 2017·Oxidative Medicine and Cellular Longevity·M JakubowskiA Doroszko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.