Chlorthalidone versus hydrochlorothiazide for the treatment of hypertension in older adults: a population-based cohort study

Annals of Internal Medicine
Irfan A DhallaDavid N Juurlink

Abstract

Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension. To compare the effectiveness and safety of chlorthalidone and hydrochlorothiazide in older adults. Propensity score-matched observational cohort study with up to 5 years of follow-up. Ontario, Canada. All individuals aged 66 years or older who were newly treated with chlorthalidone or hydrochlorothiazide and were not hospitalized for heart failure, stroke, or myocardial infarction in the prior year were eligible for inclusion. Each chlorthalidone recipient was matched to up to 2 hydrochlorothiazide recipients on the basis of age, sex, year of treatment initiation, and propensity score. The primary outcome was a composite of death or hospitalization for heart failure, stroke, or myocardial infarction. Safety outcomes included hospitalization with hypokalemia or hyponatremia. A total of 29 873 patients were studied. During follow-up, chlorthalidone recipients (n = 10 384) experienced the primary outcome at a rate of 3.2 events per 100 person-years of follow-up, and hydrochlorothiazide recipients experienced 3.4 events per 100 person-years of follow-up (adjusted hazard ratio, 0.93 [95% CI, 0.81 to 1.06]). Patients t...Continue Reading

Citations

Jul 11, 2013·Current Hypertension Reports·George C RoushTheodore R Holford
Jun 6, 2013·Current Opinion in Cardiology·George C RoushMichael E Ernst
Apr 9, 2014·Clinical Interventions in Aging·Edelgard Anna KaiserHans Hendrik Schäfer
Sep 21, 2013·Journal of the American Medical Informatics Association : JAMIA·Jimeng SunBradley A Malin
Apr 8, 2014·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Lindsey W Crist, Dave L Dixon
May 9, 2014·The American Journal of Medicine·Jan C van BlijderveenKatia M Verhamme
Jun 28, 2014·Current Hypertension Reports·David Parra, Augustus Hough
Oct 8, 2015·Drugs & Aging·Thiruvinvamalai S Dharmarajan, Lekshmi Dharmarajan
Mar 12, 2015·Future Cardiology·James J DiNicolantonioJames H O'Keefe
Sep 25, 2014·Annual Review of Pharmacology and Toxicology·R D FeldmanS W Tobe
Aug 17, 2016·Pharmacoepidemiology and Drug Safety·Diana MartinsOntario Drug Policy Research Network
Mar 25, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Herman KwokTara Gomes
Nov 19, 2013·Journal of Cardiovascular Pharmacology and Therapeutics·George C RoushMichael E Ernst
Nov 25, 2015·Canadian Pharmacists Journal : CPJ = Revue Des Pharmaciens Du Canada : RPC·Arden R BarryMargaret L Ackman
Apr 7, 2015·CMAJ Open·Suzanne D TurnerIrfan A Dhalla
Oct 9, 2019·Journal of Human Hypertension·Stela DinevaToni Vekov
May 16, 2014·Journal of the American Geriatrics Society·Anil N MakamMichael A Steinman
Oct 22, 2014·Journal of the American Geriatrics Society·Joseph T HanlonKenneth E Schmader
Oct 20, 2017·BMC Geriatrics·Christina SommerauerAndreas Sönnichsen
Feb 27, 2015·American Journal of Therapeutics·Pramod Reddy, Lori Dupree
Jun 3, 2014·Expert Review of Cardiovascular Therapy·William L BakerWilliam B White

Related Concepts

Antihypertensive Agents
Thalitone
Hospitalization
Sectrazide
Hypertensive Disease
Hypokalemia
Hyponatremia
Retrospective Studies
Propensity Score
Chlorthalidone

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.