Abstract
While a diet rich in anti-oxidant has been favorably associated with coronary disease and hypertension, limited data have evaluated the influence of such diet on subclinical disease. Thus, we sought to examine whether chocolate consumption is associated with calcified atherosclerotic plaque in the coronary arteries (CAC). In a cross-sectional design, we studied 2217 participants of the NHLBI Family Heart Study. Chocolate consumption was assessed by a semi-quantitative food frequency questionnaire and CAC was measured by cardiac CT. We defined prevalent CAC using an Agatston score of at least 100 and fitted generalized estimating equations to calculate prevalence odds ratios of CAC. There was an inverse association between frequency of chocolate consumption and prevalent CAC. Odds ratios (95% CI) for CAC were 1.0 (reference), 0.94 (0.66-1.35), 0.78 (0.53-1.13), and 0.68 (0.48-0.97) for chocolate consumption of 0, 1-3 times per month, once per week, and 2+ times per week, respectively (p for trend 0.022), adjusting for age, sex, energy intake, waist-hip ratio, education, smoking, alcohol consumption, ratio of total-to-HDL-cholesterol, non-chocolate candy, and diabetes mellitus. Controlling for additional confounders did not alter...Continue Reading
Citations
Sep 7, 2011·Current Atherosclerosis Reports·Owais KhawajaLuc Djoussé
Apr 8, 2011·Antioxidants & Redox Signaling·David L KatzAther Ali
Feb 14, 2012·Nutrition Journal·José Ignacio Recio-RodríguezUNKNOWN Vaso-Risk group
Jun 15, 2011·Maturitas·L Fernández-MurgaA Cano
Oct 13, 2015·Current Treatment Options in Cardiovascular Medicine·Erin Higginbotham, Pam R Taub
May 27, 2015·Obesity·Chelsey L KeelerSze-Yen Tan
Dec 3, 2013·JACC. Cardiovascular Imaging·Adela HrubyNicola M McKeown
Mar 3, 2015·American Heart Journal·Jeremy M RobbinsLuc Djoussé
Aug 9, 2018·Praxis·Christine Attenhofer JostFranz Wolfgang Amann
Aug 1, 2018·Heart·Yongcheng RenDong-Sheng Hu
Aug 1, 2013·American Journal of Physiology. Endocrinology and Metabolism·Kashif M MunirMichael J Quon
Jan 17, 2015·Advances in Nutrition·Roberta L DuyffBrian Wansink
Oct 17, 2017·Frontiers in Nutrition·Ivan M Petyaev, Yuriy K Bashmakov
Jan 1, 2015·Current Opinion in Lipidology·Lindsey M BerendsAedin Cassidy
Jul 20, 2012·The American Journal of Clinical Nutrition·Andrea De GottardiJaime Bosch
Aug 2, 2018·Genes & Nutrition·Charlotte C J R MichielsenLydia A Afman
Apr 5, 2013·The American Journal of Clinical Nutrition·Peter J CurtisAedín Cassidy
Jul 20, 2021·European Journal of Nutrition·Ania StolarczykLuc Djousse
Aug 17, 2021·Heart, Lung & Circulation·Ioana MozosConstantin Tudor Luca
Dec 31, 2019·Current Medicinal Chemistry·Hongwei SiDongmin Liu