Chocolate consumption is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the NHLBI Family Heart Study.

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Luc DjousséR Curtis Ellison

Abstract

While a diet rich in anti-oxidant has been favorably associated with coronary disease and hypertension, limited data have evaluated the influence of such diet on subclinical disease. Thus, we sought to examine whether chocolate consumption is associated with calcified atherosclerotic plaque in the coronary arteries (CAC). In a cross-sectional design, we studied 2217 participants of the NHLBI Family Heart Study. Chocolate consumption was assessed by a semi-quantitative food frequency questionnaire and CAC was measured by cardiac CT. We defined prevalent CAC using an Agatston score of at least 100 and fitted generalized estimating equations to calculate prevalence odds ratios of CAC. There was an inverse association between frequency of chocolate consumption and prevalent CAC. Odds ratios (95% CI) for CAC were 1.0 (reference), 0.94 (0.66-1.35), 0.78 (0.53-1.13), and 0.68 (0.48-0.97) for chocolate consumption of 0, 1-3 times per month, once per week, and 2+ times per week, respectively (p for trend 0.022), adjusting for age, sex, energy intake, waist-hip ratio, education, smoking, alcohol consumption, ratio of total-to-HDL-cholesterol, non-chocolate candy, and diabetes mellitus. Controlling for additional confounders did not alter...Continue Reading

Citations

Sep 7, 2011·Current Atherosclerosis Reports·Owais KhawajaLuc Djoussé
Apr 8, 2011·Antioxidants & Redox Signaling·David L KatzAther Ali
Feb 14, 2012·Nutrition Journal·José Ignacio Recio-RodríguezUNKNOWN Vaso-Risk group
Jun 15, 2011·Maturitas·L Fernández-MurgaA Cano
Oct 13, 2015·Current Treatment Options in Cardiovascular Medicine·Erin Higginbotham, Pam R Taub
Dec 3, 2013·JACC. Cardiovascular Imaging·Adela HrubyNicola M McKeown
Aug 9, 2018·Praxis·Christine Attenhofer JostFranz Wolfgang Amann
Oct 17, 2017·Frontiers in Nutrition·Ivan M Petyaev, Yuriy K Bashmakov
Jan 1, 2015·Current Opinion in Lipidology·Lindsey M BerendsAedin Cassidy
Aug 2, 2018·Genes & Nutrition·Charlotte C J R MichielsenLydia A Afman
Aug 17, 2021·Heart, Lung & Circulation·Ioana MozosConstantin Tudor Luca
Dec 31, 2019·Current Medicinal Chemistry·Hongwei SiDongmin Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.