PMID: 19943525Dec 1, 2009Paper

Choice of statistical approaches and analysis of blood serum proteome profiles in an experiment with 24-hour head-down tilt (-15 degrees)

Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine
N A PakharukovaIrina M Larina

Abstract

Variability analysis of normal human proteoma requires a valid and crisp algorithm for mass-spectrometry data analysis. The goal was to test methods of statistical analysis of blood serum proteoma profiles in an experiment with 24-hr. HDT using the small sample nonparametric criteria. The investigation revealed peaks that appear to be a molecular response of organism to simulated microgravity. Further identification of fiducially mobile peaks with the help of tandem mass-spectrometry will enable disclosure of subtle mechanisms of adaptation to the spaceflight factors and improvement of human health evaluation in space missions of varying length.

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