Choices aplenty: antifungal prophylaxis in hematopoietic stem cell transplant recipients

Bone Marrow Transplantation
N S HamzaHillard M Lazarus

Abstract

The incidence of invasive fungal infection (IFIs) in hematopoietic stem cell transplantation (HSCT) recipients ranges from 10 to 25% with an overall case fatality rate of up to 70-90%. Candida and Aspergillus genera remain the two most common pathogens. Although fluconazole prophylaxis in this population has been moderately effective in reducing mortality due to invasive candidiasis, this agent does not have activity against invasive aspergillosis (IA) and other mould. Several new agents such as voriconazole and caspofungin have enhanced potency and broad-spectrum antifungal activity and show promising results against yeasts and filamentous fungi when given as therapy and as chemoprophylaxis. Further, new diagnostic tools to detect circulating fungal antigens in biological fluids and PCR-based methods to detect species or genus-specific DNA or RNA have been developed. Incorporating these techniques along with clinical criteria appear to improve the accuracy of preclinical diagnosis of IFIs. Such approaches may alter the current treatment strategy from prophylaxis to pre-emptive therapy, thereby potentially decreasing cost and toxicity in high-risk patients.

References

Jun 1, 1995·The Journal of Infectious Diseases·T F PattersonV T Andriole
Dec 1, 1994·The American Journal of Medicine·D K RileyT G Evans
Jun 1, 1994·Annals of Internal Medicine·F MenichettiUNKNOWN GIMEMA Infection Program
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D Abi-SaidS Vartivarian
Jul 1, 1997·Clinical Microbiology Reviews·O Lortholary, B Dupont
Nov 24, 1999·Journal of Clinical Pathology·P C HuijgensA R Jonkhoff
Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M NucciW Pulcheri
May 5, 2000·The Cochrane Database of Systematic Reviews·P C Gotzsche, H K Johansen
Sep 22, 2000·Archives of Internal Medicine·J AbbasI Raad
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S J LinS M Teutsch
Feb 24, 2001·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M N Neely, M A Ghannoum
Apr 17, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J W BaddleyP G Pappas
Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A DykewiczUNKNOWN American Society of Blood and Marrow Transplantation
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J StrahilevitzD Engelhard
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
Jan 22, 2002·The Journal of Antimicrobial Chemotherapy·David A Stevens
Jan 25, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David W DenningHartmut Lode
Feb 14, 2002·British Journal of Haematology·Rodrigo MartinoUNKNOWN alloPBSCT Infectious/Non-infectious Complications Subcommittees of the Grupo Español de Trasplante Hematopoyético (GETH)
Mar 7, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kieren A MarrLawrence Corey
Mar 7, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·François BoutboulPatricia Ribaud
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Raoul HerbrechtErmanno Candolfi
Mar 29, 2002·The Hematology Journal : the Official Journal of the European Haematology Association·A UlusakaryaJ N Munck
Apr 9, 2002·Journal of Clinical Pharmacology·Hillard M LazarusAlain Romero

❮ Previous
Next ❯

Citations

Mar 25, 2008·Therapeutics and Clinical Risk Management·Gregory EschenauerPeggy L Carver
Feb 2, 2006·Expert Opinion on Pharmacotherapy·Tuhina Raman, Paul E Marik
Jun 20, 2006·The Surgical Clinics of North America·Daniel F Flynn, Ronald E Goans
Jan 9, 2007·International Journal of Antimicrobial Agents·Matthew E FalagasGeorge Samonis
Jun 2, 2005·American Journal of Hematology·Michael Koldehoff, Johames L Zakrzewski
Jan 5, 2006·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M KoldehoffD W Beelen
Jul 11, 2006·Clinical Transplantation·Sharon EladReuven Or
Apr 28, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K MullaneP Stiff
Nov 29, 2007·Pharmacotherapy·Lillian S ChouDimitrios P Kontoyiannis
Mar 4, 2011·Journal of Clinical Pharmacy and Therapeutics·B des Champs-BroB Sendid
Apr 8, 2015·Bioscience, Biotechnology, and Biochemistry·Soichi Furukawa
Jan 8, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·I AmiguesGenovefa A Papanicolaou
Jan 11, 2005·Clinical Journal of Oncology Nursing·Fran West, Sandra A Mitchell
Jun 9, 2016·Expert Review of Anti-infective Therapy·Frank P TverdekDimitrios P Kontoyiannis
Oct 17, 2007·Annual Review of Medicine·A Simon Lynch, Gregory T Robertson
Dec 9, 2016·Expert Opinion on Drug Safety·Ioannis KyriakidisAndreas H Groll
Mar 20, 2016·Biointerphases·Leanne E FisherBo Su
Jun 3, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mauricette Michallet, James I Ito
Jun 6, 2018·Antimicrobial Agents and Chemotherapy·Cho-Hao LeeJung-Chung Lin
Sep 1, 2006·Medical Mycology·Elpis Mantadakis, George Samonis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.