ChoK-ing the Pathogenic Bacteria: Potential of Human Choline Kinase Inhibitors as Antimicrobial Agents.

BioMed Research International
Moad KhalifaWei Cun See Too

Abstract

Novel antimicrobial agents are crucial to combat antibiotic resistance in pathogenic bacteria. Choline kinase (ChoK) in bacteria catalyzes the synthesis of phosphorylcholine, which is subsequently incorporated into the cell wall or outer membrane. In certain species of bacteria, phosphorylcholine is also used to synthesize membrane phosphatidylcholine. Numerous human ChoK inhibitors (ChoKIs) have been synthesized and tested for anticancer properties. Inhibition of S. pneumoniae ChoK by human ChoKIs showed a promising effect by distorting the cell wall and retarded the growth of this pathogen. Comparison of amino acid sequences at the catalytic sites of putative choline kinases from pathogenic bacteria and human enzymes revealed striking sequence conservation that supports the potential application of currently available ChoKIs for inhibiting bacterial enzymes. We also propose the combined use of ChoKIs and nanoparticles for targeted delivery to the pathogen while shielding the human host from any possible side effects of the inhibitors. More research should focus on the verification of putative bacterial ChoK activities and the characterization of ChoKIs with active enzymes. In conclusion, the presence of ChoK in a wide range o...Continue Reading

References

Apr 14, 1999·Molecular Microbiology·J R ZhangE I Tuomanen
Jul 3, 1999·The Journal of Biological Chemistry·K E de RudderO Geiger
Apr 12, 2002·The Lancet Infectious Diseases·Isaac Ginsburg
Jun 5, 2002·Annual Review of Biochemistry·Christian R H Raetz, Chris Whitfield
Jan 28, 2003·Progress in Lipid Research·Christian SohlenkampOtto Geiger
Nov 18, 2003·Molecular Microbiology·Xin FanJeffrey N Weiser
Feb 6, 2004·Molecular Microbiology·Claudia KentJ Christopher Fenno
Nov 13, 2004·FEMS Microbiology Reviews·Rubens López, Ernesto García
Jul 8, 2005·Applied and Environmental Microbiology·Dagmar KapfhammerPaula I Watnick
Feb 18, 2006·Journal of Bacteriology·Diego J ComerciRodolfo A Ugalde
Mar 2, 2006·Expert Opinion on Drug Delivery·Lilian E van Vlerken, Mansoor M Amiji
Apr 22, 2006·Biochimica Et Biophysica Acta·Vinay ChoubeyUday Bandyopadhyay
Nov 25, 2006·The Journal of Antimicrobial Chemotherapy·Larissa GrigoryanUNKNOWN SAR group
Dec 6, 2006·Antimicrobial Agents and Chemotherapy·Vinay ChoubeyUday Bandyopadhyay
Dec 13, 2006·Nature Reviews. Drug Discovery·David J PayneDavid L Pompliano
Mar 17, 2007·Annual Review of Biochemistry·Christian R H RaetzRussell E Bishop
Apr 13, 2007·Clinical Microbiology Reviews·Stephen TristramPeter C Appelbaum
Feb 22, 2008·Current Pharmaceutical Biotechnology·Adam W Barb, Pei Zhou
Apr 3, 2008·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Julian Davies

❮ Previous
Next ❯

Citations

Jul 3, 2021·Genes·Siti Aisyah Faten Mohamed Sa'domLing Ling Few

❮ Previous
Next ❯

Methods Mentioned

BETA
phosphotransferase
acylation

Related Concepts

Related Feeds