Chokeberry attenuates the expression of genes related to de novo lipogenesis in the hepatocytes of mice with nonalcoholic fatty liver disease

Nutrition Research
Hyunjin ParkJung-Hee Shin

Abstract

Nonalcoholic fatty liver disease (NAFLD), which is characterized by steatosis, is a major public health concern. Previous studies have shown that chokeberry has anti-inflammatory, antimutagenic, hepatoprotective, cardioprotective, and antidiabetic effects. In this study, we hypothesized that chokeberry powder can attenuate the expression of genes related to de novo lipogenesis and the triglyceride levels in the hepatocytes of mice with high-fat diet-induced NAFLD. After coadministering chokeberry powder for 8weeks (0.5% and 1% powder) with a high-fat diet, mice that consumed chokeberry powder diets, regardless of the dose, had significantly lower liver triglyceride levels than control mice that were fed a high-fat diet (P=.0145 and P<.0012, respectively). Compared with mice that were fed a high-fat diet, mice that were given 1% chokeberry powder exhibited significantly decreased mRNA expression of sterol regulatory element-binding protein (P=.009) and acetyl-CoA carboxylase (P=.0032) in the liver. Compared with mice in the control group, fatty acid synthase (FAS) expression significantly increased in the mice that were fed a high-fat diet, but both chokeberry powder-treated groups had significantly decreased FAS expression (P=....Continue Reading

References

Aug 1, 1997·The British Journal of Nutrition·V K Atanasova-GoranovaG T Pevicharova
Nov 23, 2000·Genes & Development·J R SchultzB Shan
Aug 22, 2001·Journal of Agricultural and Food Chemistry·M P KähkönenM Heinonen
Jan 9, 2003·Journal of Agricultural and Food Chemistry·Wei Zheng, Shiow Y Wang
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Bryan A LaffittePeter Tontonoz
Jul 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Guoxun ChenMichael S Brown
Jan 1, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·S Valcheva-KuzmanovaA Belcheva
Dec 1, 2006·Plant Foods for Human Nutrition·S Valcheva-KuzmanovaA Belcheva
Apr 19, 2007·Methods and Findings in Experimental and Clinical Pharmacology·S Valcheva-KuzmanovaA Belcheva
Jun 5, 2007·Clinics in Liver Disease·Abdurrahman KadayifciNathan M Bass
Oct 4, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jong-Hee HwangMeredith Hawkins
Apr 1, 2008·Cancer Letters·K GasiorowskiJ Oszmiański
May 8, 2008·Current Opinion in Lipidology·Steve S Choi, Anna Mae Diehl
Feb 23, 2010·Journal of Medicinal Food·Adam KokotkiewiczMaria Luczkiewicz
Dec 9, 2010·International Journal of Food Sciences and Nutrition·Małgorzata GumiennaZbigniew Czarnecki
Aug 25, 2011·European Journal of Nutrition·D Zapolska-DownarD Sitkiewicz
Nov 9, 2011·Health Technology Assessment : HTA·D ShyangdanN Waugh
Jun 7, 2013·International Journal of Molecular Sciences·Giridhar Kanuri, Ina Bergheim
Jan 24, 2014·European Journal of Nutrition·Joanna SikoraElżbieta Mikiciuk-Olasik
Dec 11, 2014·World Journal of Gastroenterology : WJG·Alessandro FedericoCarmela Loguercio
Apr 29, 2015·Journal of Hepatology·Christopher D Byrne, Giovanni Targher

❮ Previous
Next ❯

Citations

Sep 19, 2016·Lipids in Health and Disease·Sabina Paglialunga, Clayton A Dehn
Jul 14, 2017·Journal of Agricultural and Food Chemistry·Shengmin ZhouLiangli Lucy Yu
Oct 18, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Katarzyna Kowalska, Anna Olejnik
Nov 7, 2019·BMC Complementary and Alternative Medicine·Chattraya NgamlerstPattaneeya Prangthip
Jul 8, 2020·International Journal of Molecular Sciences·Da Eun KimSung Yeon Kim
Jul 3, 2021·International Journal of Molecular Sciences·Kamila Kasprzak-DrozdAnna Oniszczuk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.