Cholangiocarcinoma: Current opinion on clinical practice diagnostic and therapeutic algorithms: A review of the literature and a long-standing experience of a referral center

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Giovanni BrandiGICO

Abstract

In the oncology landscape, cholangiocarcinoma is a challenging disease in terms of both diagnosis and treatment. Besides anamnesis and clinical examination, a definitive diagnosis of cholangiocarcinoma should be supported by imaging techniques (US, CT, MRI) and invasive investigations (ERC or EUS with brushing and FNA or US or CT-guided biopsy) followed by pathological confirmation. Surgery is the main curative option, so resectability of the tumour should be promptly assessed. Moreover, jaundice must be evaluated at the outset because biliary tract decompression with drainage and stent placement may be required. If the patient is resectable, pre-operative assessment of postoperative liver function is mandatory. After a curative resection, an adjuvant therapy may be administered. Otherwise, in cases with macroscopic residual disease after surgery or locally recurrent or unresectable cholangiocarcinoma at the diagnosis, first-line chemotherapy is the preferred strategy, possibly associated with radiotherapy and/or locoregional treatments. As the diagnostic and therapeutic pathway for cholangiocarcinoma can be declined in different modalities, patients should be promptly referred to a multidisciplinary team in a tertiary centre, ...Continue Reading

References

Aug 1, 1994·The British Journal of Surgery·E C LaiJ Wong
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·M E Alden, M Mohiuddin
Feb 12, 1998·The New England Journal of Medicine·E J Nieveen van DijkumD J Gouma
May 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·I De VreedeG J Gores
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T Patel
Aug 23, 2003·AJR. American Journal of Roentgenology·Jae Hoon Lim
Jun 12, 2004·Seminars in Liver Disease·Yasser Shaib, Hashem B El-Serag
Jun 26, 2004·Oncology·Matthew J Olnes, Rodrigo Erlich
Jul 16, 2005·Surgical Oncology·D SinghalD J Gouma
Aug 11, 2005·The Kaohsiung Journal of Medical Sciences·Yi-You ChiouCheng-Yen Chang
Oct 11, 2005·Lancet·Shahid A KhanSimon D Taylor-Robinson
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wells A MessersmithDeborah K Armstrong
Mar 21, 2006·Journal of Hepato-biliary-pancreatic Surgery·Hiroki KawashimaHidemi Goto
Mar 27, 2007·Journal of Hepato-biliary-pancreatic Surgery·Yukihiro YokoyamaYuji Nimura
Jul 21, 2007·Human Pathology·Kevin C Halling, Benjamin R Kipp
Oct 16, 2007·Surgical Oncology·Steven C CunninghamTimothy M Pawlik
Nov 8, 2007·Annals of Surgical Oncology·Jensen C C TanCalvin H L Law
Jan 23, 2008·Journal of Clinical Gastroenterology·Patrick Yachimski, Daniel S Pratt
Jan 29, 2008·Gastroenterology·Amaar GhazaleMichael B Farnell
Feb 16, 2008·Journal of Hepato-biliary-pancreatic Surgery·Toshio TsuyuguchiUNKNOWN Japan Society of Clinical Oncology
May 2, 2008·The Oncologist·Aram F Hezel, Andrew X Zhu
Sep 6, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·H WitzigmannH Lauer
Sep 6, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·S A KhanS D Taylor-Robinson
Sep 6, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·V Vilgrain
Sep 13, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Phunchai CharatcharoenwitthayaKeith D Lindor
Nov 26, 2008·World Journal of Gastroenterology : WJG·Yucel Ustundag, Yusuf Bayraktar
Jan 27, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Y G Li, N Zhang
Jan 27, 2009·Cancer Chemotherapy and Pharmacology·Ramesh K RamanathanDavid R Gandara
Mar 19, 2009·World Journal of Surgery·Alfredo GuglielmiCalogero Iacono
Mar 25, 2009·Surgical Oncology Clinics of North America·David J ReaGregory J Gores
Mar 28, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Clifton David FullerMartin Fuss
May 2, 2009·BMC Gastroenterology·Kawin LeelawatJerasak Wannaprasert
May 21, 2009·Journal of Hepato-biliary-pancreatic Sciences·Fei GaoZhao-Shen Li
Nov 17, 2009·International Journal of Radiation Oncology, Biology, Physics·Hee Keun GwakJeong Hoon Park
Jun 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sam J LubnerKyle D Holen

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Citations

Dec 24, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni BrandiFrancesco Tovoli
Jan 23, 2017·Current Gastroenterology Reports·Bryan DohertyWilliam C Palmer
Jun 2, 2018·Medicinal Research Reviews·Hui HuaYangfu Jiang
Nov 1, 2018·Virchows Archiv : an International Journal of Pathology·Samantha SarcognatoMaria Guido
Apr 17, 2018·Minerva chirurgica·Enrico PinottiLuca Gianotti
Oct 28, 2019·European Journal of Gastroenterology & Hepatology·Jorge Nicolas RuizFrank J Lukens
Feb 16, 2020·Cells·Giovanni Brandi, Simona Tavolari
Sep 25, 2017·Oncotarget·Bruno Christian KöhlerChristoph Springfeld
Apr 10, 2020·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Jing WangJianfeng Yang
Jul 23, 2020·Journal of Hepato-biliary-pancreatic Sciences·Qingshan LiYi Lv
Oct 13, 2016·World Journal of Gastroenterology : WJG·María-Victoria Alvarez-Sánchez, Bertrand Napoléon
Mar 15, 2018·World Journal of Surgery·Jarmo NiemeläHannu Syrjälä
Mar 19, 2020·Gastroenterology Research and Practice·Sulai LiuBo Jiang
Sep 10, 2020·Frontiers in Oncology·Angelo Virgilio ParadisoNicola Silvestris
Aug 4, 2020·World Journal of Gastroenterology : WJG·Daniele DondossolaDiego Foschi
Feb 14, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Matthew C HernandezMark J Truty
Nov 30, 2016·Oncology Letters·Wayne A WarnerRavi Maharaj
Sep 4, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lipika GoyalDan G Duda
Dec 18, 2020·Seminars in Interventional Radiology·Pouya Entezari, Ahsun Riaz
Feb 10, 2021·International Journal of Cancer. Journal International Du Cancer·Nadia Emad Lotfi AminLars Henrik Jensen
Mar 13, 2021·World Journal of Hepatology·Alina Ioana TantauVoicu Mercea
Jun 3, 2021·Diagnostics·Preawwalee WintachaiApinya Jusakul
May 28, 2021·World Journal of Gastrointestinal Oncology·Gianluca RompianesiRoberto Troisi
Sep 17, 2021·Technology in Cancer Research & Treatment·Fan-Li Zeng, Jing-Fang Chen

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