Cholangiocarcinoma with intraductal tubular growth pattern versus intraductal papillary growth pattern

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Tetsuo TsukaharaMasato Nagino

Abstract

Intraductal neoplasms of the bile duct are macroscopically characterized by exophytic or polypoid growth patterns and have a favorable prognosis. Although some tumors with a predominantly tubular microscopic pattern have been reported, they have not been well characterized clinicopathologically. The purpose of the present study was to compare the newly recognized cholangiocarcinoma with an intraductal tubular growth pattern and cholangiocarcinoma with an intraductal papillary growth pattern and to investigate the pathological and prognostic significance of the former. This study analyzed 161 patients with tumors with exophytic or polypoid growth patterns from a large series of 733 cholangiocarcinoma cases surgically resected from January 1998 to May 2013. The study patients were divided into two groups: those whose tumors showed a predominantly tubular growth pattern (n=52) and those whose tumors exhibited a predominantly papillary growth pattern (n=109). Tubular growth pattern was associated with combined vascular resection and the absence of macroscopic mucin. Several histological indexes were significantly higher for the tubular growth pattern than the papillary one, including tubular adenocarcinoma, depth of invasion, micro...Continue Reading

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Citations

Nov 3, 2017·Abdominal Radiology·Isabelle DurotJürgen K Willmann
Jul 12, 2018·Revista do Colégio Brasileiro de Cirurgiões·Rodrigo Vieira GomesVivian Resende
Apr 10, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Shunsuke OnoeMasato Nagino
Aug 17, 2021·Seminars in Interventional Radiology·Juan C CamachoAnne M Covey

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