Cholecystectomy Causes Ultrasound Evidence of Increased Hepatic Steatosis

World Journal of Surgery
Sangchul YunSeung Sam Paik

Abstract

Cholecystectomy might contribute to the development of hepatic steatosis through metabolic changes. The biologic alteration of the enterohepatic circulation of bile acids and the alteration of the metabolic activity of bile acid that follows cholecystectomy may contribute to hepatic steatosis. This prospective study was conducted to clarify the possibility of steatosis development after cholecystectomy. From October 2013 to July 2014, 82 consecutive patients with a presumptive diagnosis of gallbladder disease were cholecystectomized. Liver parenchymal steatosis was measured using ultrasound and the hepatic steatosis index. In all 82 patients, the hepatic steatosis index was found to be significantly correlated with the US fatty liver grade (Spearman's correlation r (2) = 0.331, P < 0.001). A total of 62 patients were followed up for 3 months. Comparison with the initial grade showed that 12 (18.5 %) patients had worsened from normal to mild (n = 10), from mild to moderate (n = 1), and from mild to severe (n = 1). The other patients stayed at their initial grade except one patient who improved (from moderated to mild). Analysis of laboratory findings showed that white blood cell count, aspartate transaminase, alanine transaminas...Continue Reading

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Jan 4, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Gabriella GarrutiPiero Portincasa
Oct 22, 2016·World Journal of Surgery·Veeravich JaruvongvanichSikarin Upala
Oct 22, 2016·World Journal of Surgery·Sangchul Yun, Dongho Choi
Sep 12, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yongsheng ChenYu Tian
Feb 17, 2019·Diabetes/metabolism Research and Reviews·Li QiYongsheng Chen
Dec 22, 2020·Terapevticheskiĭ arkhiv·N A CherkashchenkoT S Krolevets
Aug 11, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Itzayana Rodríguez-AntonioNatalia Nuño-Lámbarri

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