Abstract
I.V. infusion of pentagastrin (20 microg/kg/h) or cholecystokinin (CCK)-8 (1 microg/kg/h) for 10 min caused secretion of salivary proteins from the parotid gland in the anaesthetized rat without any accompanying overt fluid secretion. This "occult" response was revealed by a subsequent wash-out injection of methacholine (5 microg/kg, I.V.) 10 min after the end of the infusion period (aiming at avoiding synergistic interactions). While the fluid response to methacholine was unaffected by the preceding infusion of pentagastrin and CCK-8, the output of protein increased by 147% (pentagastrin) and 74% (CCK-8) and that of amylase by 45% (CCK-8) compared to the responses to methacholine upon saline infusion. Those increases were abolished by the CCK-A receptor blocker (lorglumide), but not by the CCK-B receptor blocker (itriglumide). Evisceration, combined sympathetic and parasympathetic denervation of the glands and assay under adrenoceptor blockade excluded contribution from the gastro-intestinal tract, central or ganglionic mechanisms and circulating catecholamines to the increase in protein/amylase. Furthermore, Western blot demonstrated CCK receptors for both A and B subtypes in normal and chronically denervated glands. In the s...Continue Reading
References
Apr 13, 1979·Brain Research·L I Larsson, J F Rehfeld
Apr 15, 1977·Experientia·P Alm, J Ekström
Feb 1, 1987·Pharmacology & Toxicology·J EkströmG Tobin
Apr 1, 1987·Pharmacology & Toxicology·J EkströmG Tobin
Jul 1, 1988·The American Journal of Physiology·J S Davison, G D Clarke
Jul 1, 1974·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·J Ekström
Nov 1, 1984·Acta Physiologica Scandinavica·J EkströmG Tobin
Mar 6, 1980·Nature·J F RehfeldJ S Morley
Sep 1, 1980·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P MalfertheinerH Ditschuneit
Nov 1, 1995·The American Journal of Physiology·S A Wank
Sep 1, 1995·General Pharmacology·Y Iwabuchi, T Masuhara
Jan 18, 1993·FEBS Letters·C R MarinoF S Gorelick
Oct 1, 1995·Cellular and Molecular Neurobiology·P BodenJ Hughes
May 26, 1998·Annals of the New York Academy of Sciences·N TakaiY Yoshida
Feb 10, 1999·The American Journal of Physiology·L IsenmanS Rothman
Apr 16, 1999·European Journal of Pharmacology·F MakovecM Impicciatore
Feb 22, 2001·Annual Review of Physiology·J A Williams
Aug 23, 2002·Scandinavian Journal of Gastroenterology·V BallabeniE Barocelli
Jan 15, 2003·Experimental Physiology·G B ProctorL Ebersole
Apr 11, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joseph R ReeveDavid A Keire
Oct 21, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jean MorissetJean Lainé
Nov 8, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joseph R ReeveTamer Coskun
Nov 10, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Jens F Rehfeld
Citations
May 13, 2014·Journal of Immunological Methods·Amal DafarHülya Cevik-Aras
Jan 24, 2014·Obesity Research & Clinical Practice·Hirotaka UedaAkio Inui
Dec 29, 2015·Journal of Physiology, Paris·Anita BeckTibor Károly Fábián
Nov 17, 2007·Regulatory Peptides·J Ekström, Hülya Cevik Aras
Mar 25, 2006·Experimental Physiology·Hülya Cevik Aras, J Ekström
Jul 22, 2008·Journal of Pineal Research·Hülya Cevik Aras, Jörgen Ekström
Jul 29, 2006·Experimental Physiology·Hülya Cevik Aras, J Ekström
Jun 8, 2018·Journal of Oral Rehabilitation·A M L PedersenJ Ekström
Sep 18, 2010·Oral Diseases·H Cevik-Aras, J Ekström
Mar 15, 2012·Journal of Anatomy·Francesco LoyJörgen Ekström
Oct 2, 2019·Endocrine Research·Amged I DafallaAyman I Sayegh
Nov 26, 2015·Oral Diseases·A VillaG Proctor
Aug 28, 2019·Nutrients·Mariarita CaroleoAntonio Brunetti
Feb 13, 2018·Autoimmunity Reviews·Kashi Raj BhattaraiHan-Jung Chae