Cholecystokinin- and secretin-releasing peptides in the intestine--a new regulatory interendocrine mechanism in the gastrointestinal tract

Regulatory Peptides
K H Herzig

Abstract

Maintenance of homeostasis in the upper small bowel is a vital process for the body and therefore highly controlled. The enteric nervous system and the endocrine system are the regulators in this process influencing each other. The endocrine system in the gut consists of the classical hormones [cholecystokinin (CCK) secretin] to evoke motility or secretion. They are under control of releasing factors which are probably influenced by the enteric nervous system. Diazepam binding inhibitor and luminal CCK-releasing factor are likely candidates for CCK-releasing peptides in the negative feedback process in the absence of pancreatic juice. Experimental evidence suggests a secretin-releasing peptide. Further studies will be needed to determine the physiological role of each of these peptides. Monitor peptide in the pancreatic juice seems to function as a specific positive enhancement for CCK release. All these peptides are inactivated by the proteolytic enzymes during the interdigestive period. The discovery of additional releasing peptides and factors is very likely.

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Citations

Dec 5, 2002·European Journal of Pharmacology·Chiu-Lung WuPaulus S Wang
Sep 2, 1999·The Surgical Clinics of North America·G Y WongM G Sarr
May 31, 2001·European Journal of Clinical Investigation·J Walkowiak, K H Herzig
Dec 21, 2002·European Journal of Clinical Investigation·J WalkowiakK-H Herzig
Jan 30, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joelle M-J RomacRodger A Liddle
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A D ConigraveE M Brown
Nov 15, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·H PelliI Nordback
Jul 29, 2008·Brain Research Reviews·Daniela M Sartor, Anthony J M Verberne
Dec 15, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Carlos R Rojas-GarcíaIvar Rønnestad
Jan 12, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A SavoieC Cahu
Feb 26, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y Lu, C Owyang
Oct 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daniela M SartorAnthony J M Verberne
Aug 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·D G DeavallR Dimaline

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