Cholecystokinin as a stimulus in drug discrimination learning

Pharmacology, Biochemistry, and Behavior
P.M. MeltonA.L. Riley


Animals were trained to discriminate a relatively low dose of the octapeptide cholecystokinin (CCK) from distilled water within the conditioned taste aversion baseline of drug discrimination learning. Specifically, rats were injected with CCK (5.6 micrograms/kg) prior to the presentation of saccharin-LiCl pairings and with the CCK vehicle prior to the presentation of saccharin alone. After 10 conditioning trials (40 days), subjects acquired the discrimination, avoiding saccharin consumption following administration of CCK and consuming the same saccharin solution following the drug vehicle. Once the discrimination was acquired, a generalization function was determined for doses above and below that of the training stimulus. At doses below the training dose of CCK (i.e., 0, 3.2, and 4.2 micrograms/kg), subjects drank at control levels, whereas at the training dose and above (10 micrograms/kg) subjects significantly reduced consumption. That a relatively low dose of CCK can be used as a discriminative stimulus within a drug discrimination design may be important in that the procedure can now be used in the assessment of the pharmacological characteristics of CCK at a dose similar to that used in other behavioral assessments of th...Continue Reading


Jan 1, 1990·Journal of Neuroscience Methods·D A Mathis, M W Emmett-Oglesby
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·J P MastropaoloA.L. Riley
Jan 1, 1985·Annals of the New York Academy of Sciences·P L Faris
Jan 1, 1985·Annals of the New York Academy of Sciences·P De WitteJ J Vanderhaeghen
Sep 1, 1973·Journal of Comparative and Physiological Psychology·J GibbsG P Smith
Nov 1, 1991·Behavioural Pharmacology·I.P. Stoleman


May 29, 2004·Psychopharmacology·Torbjörn U C JärbeAlexandros Makriyannis
Feb 12, 2008·Psychopharmacology·Torbjörn U C JärbeAlexandros Makriyannis
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·P.M. Melton, A.L. Riley
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·S. Pournaghash, A.L. Riley
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·S.T. Smurthwaite, A.L. Riley
May 1, 1994·Pharmacology, Biochemistry, and Behavior·P.M. Melton, A.L. Riley
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·M A FoxA.L. Riley
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·A K GoodwinLisa E Baker
May 1, 1997·Pharmacology, Biochemistry, and Behavior·D V GauvinF A Holloway
May 26, 1999·Pharmacology, Biochemistry, and Behavior·S A VarvelL D Karan
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·F van HaarenW R Kem
Apr 15, 2000·Pharmacology, Biochemistry, and Behavior·K G Anderson, F van Haaren
Nov 27, 2018·Physiological Reviews·Lindsey A Schier, Alan C Spector

Related Concepts

Avoidance Learning
Chloride Ion Level
Discrimination Learning
Dose-Response Relationship, Drug
Generalization, Stimulus
Saccharin Sodium
Taste Perception

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.