Cholecystokinin as a stimulus in drug discrimination learning

Pharmacology, Biochemistry, and Behavior
P.M. MeltonA.L. Riley

Abstract

Animals were trained to discriminate a relatively low dose of the octapeptide cholecystokinin (CCK) from distilled water within the conditioned taste aversion baseline of drug discrimination learning. Specifically, rats were injected with CCK (5.6 micrograms/kg) prior to the presentation of saccharin-LiCl pairings and with the CCK vehicle prior to the presentation of saccharin alone. After 10 conditioning trials (40 days), subjects acquired the discrimination, avoiding saccharin consumption following administration of CCK and consuming the same saccharin solution following the drug vehicle. Once the discrimination was acquired, a generalization function was determined for doses above and below that of the training stimulus. At doses below the training dose of CCK (i.e., 0, 3.2, and 4.2 micrograms/kg), subjects drank at control levels, whereas at the training dose and above (10 micrograms/kg) subjects significantly reduced consumption. That a relatively low dose of CCK can be used as a discriminative stimulus within a drug discrimination design may be important in that the procedure can now be used in the assessment of the pharmacological characteristics of CCK at a dose similar to that used in other behavioral assessments of th...Continue Reading

References

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Citations

May 29, 2004·Psychopharmacology·Torbjörn U C JärbeAlexandros Makriyannis
Feb 12, 2008·Psychopharmacology·Torbjörn U C JärbeAlexandros Makriyannis
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·P.M. Melton, A.L. Riley
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·S. Pournaghash, A.L. Riley
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·S.T. Smurthwaite, A.L. Riley
May 1, 1994·Pharmacology, Biochemistry, and Behavior·P.M. Melton, A.L. Riley
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·M A FoxA.L. Riley
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·A K GoodwinLisa E Baker
May 1, 1997·Pharmacology, Biochemistry, and Behavior·D V GauvinF A Holloway
May 26, 1999·Pharmacology, Biochemistry, and Behavior·S A VarvelL D Karan
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·F van HaarenW R Kem
Apr 15, 2000·Pharmacology, Biochemistry, and Behavior·K G Anderson, F van Haaren
Nov 27, 2018·Physiological Reviews·Lindsey A Schier, Alan C Spector

Related Concepts

Metazoa
Avoidance Learning
Chloride Ion Level
Discrimination Learning
Dose-Response Relationship, Drug
Generalization, Stimulus
Lithium
Saccharin Sodium
Kinevac
Taste Perception

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