Cholecystokinin (CCK) secretion in patients with severe short bowel syndrome (SSBS)

Digestive Diseases and Sciences
P R LingB R Bistrian

Abstract

This study examined the effects of a liquid meal on cholecystokinin (CCK) secretion in patients with severe short bowel syndrome (SSBS) receiving home total parenteral nutrition (TPN) support for 5-19 years after massive small bowel resection. Five patients with SSBS due to superior mesenteric artery or vein thrombosis were included. Five healthy volunteers served as controls. Blood was drawn before and 1 hr following consumption of 250 ml of a liquid diet containing 232 kcal with 8 g fat and 8 g protein. Plasma CCK activity was evaluated by amylase bioassay. All patients had stable weight with a normal BMI and serum albumin level, although there were mild abnormalities in their liver function tests. CCK secretion after stimulation was significantly decreased in patients. These results suggest that reduction in intestinal length influences CCK secretion in response to meal stimulation in SSBS patients.

Citations

Mar 22, 2002·Pediatric Transplantation·Stuart S Kaufman
Jun 15, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Vanessa J Kumpf
Jan 2, 2007·Journal of Clinical Gastroenterology·Evangelos P MisiakosTheodore Liakakos
Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Olivier Goulet, Frédérique Sauvat
Apr 13, 2004·Journal of Pediatric Gastroenterology and Nutrition·Olivier GouletVirginie Colomb
Dec 4, 2003·Best Practice & Research. Clinical Gastroenterology·Jon A Vanderhoof, Rosemary J Young
Jun 13, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F W GuglielmiA Francavilla
Oct 31, 2007·Gastrointestinal Endoscopy Clinics of North America·Alan L Buchman

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