Cholecystokinin metabolism in man and dogs.

Annals of Surgery
J C ThompsonP L Rayford

Abstract

We have developed a sensitive, specific and reproducible radioimmunoassay for cholecystokinin (CCK) with which basal levels of CCK of between 400-800 pg/ml have been measured in normal man, in patients with diabetes and with duodenal ulcer disease, and in normal dogs. After a meal, circulating levels of CCK rose to 1000-1200 pg/ml in human subjects. Release of CCK was more rapid in diabetic and duodenal ulcer patients than in normal subjects, but elevated postprandial levels persisted much longer in normal subjects. Patients with the Zollinger-Ellison syndrome had elevated values of cholecystokinin which rose after a meal. Lack of correlation between elevated basal levels of gastrin and CCK in patients with the Zollinger-Ellison syndrome suggest that the hypercholecystokininemia may be absolute. The disappearance half-time of exogenous CCK was about 21/2 minutes in normal subjects as well as in diabetic and duodenal ulcer patients. Studies in dogs demonstrated no uptake of basal levels of cholecystokinin by the kidney; on infusion of exogenous CCK-33, the kidney extracted 43% of the total CCK presented and 56% of the integrated CCK. We conclude that: 1) circulating basal and postprandial levels of CCK may be measured in a repro...Continue Reading

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Citations

Aug 31, 1979·World Journal of Surgery·P L RayfordJ C Thompson
Nov 1, 1995·Digestive Diseases and Sciences·R PatankarC D Johnson
Dec 1, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·W Schlegel, S Raptis
May 1, 1993·Pharmacology, Biochemistry, and Behavior·R L Corwin, C R Schuster
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·R D SimmonsJ R Rosamond
Dec 1, 1989·Regulatory Peptides·J C CuberJ A Chayvialle
Aug 1, 1997·Journal of Hepatology·L I PaloheimoJ F Rehfeld
Dec 10, 1999·Journal of the American College of Surgeons·S RätyI Nordback
May 13, 1976·The New England Journal of Medicine·P L RayfordJ C Thompson
May 1, 1990·Gut·P A GraceR C Williamson
Nov 1, 1976·The Journal of Clinical Investigation·D S EmmanouelA H Huen
Feb 23, 2012·The Pan African Medical Journal·Ugwu Anthony ChukwukaOkechukwu Felix Erondu
Jan 1, 1994·Developmental Psychobiology·D N Lorenz
Nov 2, 2006·Journal of Neuroendocrinology·A C HeijboerE P M Corssmit
Dec 1, 1984·American Journal of Surgery·K R SirinekB A Levine
Feb 1, 1989·The Journal of Surgical Research·F E JohnsonJ E Devine
May 1, 1984·The Journal of Surgical Research·W T ChanceJ E Fischer
Sep 1, 1985·Journal of Clinical Ultrasound : JCU·P JouppilaP Kirkinen
Nov 1, 1991·Scandinavian Journal of Gastroenterology·T AokiE Sasaki
Dec 27, 1982·Life Sciences·K L CoxC K Iwahashi-Hosoda
Nov 16, 1984·Journal of Immunological Methods·R F MurphyS N Joffe
Nov 1, 1981·General and Comparative Endocrinology·H G Pollock, J R Kimmel
Jul 1, 1978·La Ricerca in Clinica E in Laboratorio·A EderleL A Scuro

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