Cholecystokinin receptor antagonism of stimulated pancreatic and gastric secretion.

The Journal of Surgical Research
Michael W Mulholland, H T Debas

Abstract

The effects of cholecystokinin receptor antagonist, dipentyl-3,4-dichloroproglumide (DDP), on stimulated pancreatic and gastric secretion were studied in the rat. DDP dose-dependently inhibited cholecystokinin-stimulated amylase release from dispersed acinar cells. In vivo, DDP inhibited cholecystokinin octapeptide-stimulated amylase and protein secretion. DDP also inhibited pentagastrin-stimulated gastric acid secretion in vivo. Meal-stimulated acid output was decreased by 34% (DDP 400 micrograms/kg/hr) but responsiveness to histamine or parachlorophenyl-gamma-aminobutyric acid was unchanged.

Citations

Sep 1, 1990·Journal of the Autonomic Nervous System·C DahlstrandH Ahlman
Jun 23, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ze-Feng XiaMichael W Mulholland
Sep 1, 1992·The Journal of Surgical Research·S ShivaramP K Chaudhuri

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