Cholecystokinin receptors mediate tolerance to the analgesic effect of TENS in arthritic rats.

Pain
Josimari M DesantanaKathleen A Sluka

Abstract

Transcutaneous electrical nerve stimulation (TENS) is a treatment for pain that involves placement of electrical stimulation through the skin for pain relief. Previous work from our laboratory shows that repeated application of TENS produces analgesic tolerance by the fourth day and a concomitant cross-tolerance at spinal opioid receptors. Prior pharmacological studies show that blockade of cholecystokinin (CCK) receptors systemically and spinally prevents the development of analgesic tolerance to repeated doses of opioid agonists. We therefore hypothesized that systemic and intrathecal blockade of CCK receptors would prevent the development of analgesic tolerance to TENS, and cross-tolerance at spinal opioid receptors. In animals with knee joint inflammation (3% kaolin/carrageenan), high (100Hz) or low frequency (4Hz) TENS was applied daily and the mechanical withdrawal thresholds of the muscle and paw were examined. We tested thresholds before and after inflammation, and before and after TENS. Animals treated systemically, prior to TENS, with the CCK antagonist, proglumide, did not develop tolerance to repeated application of TENS on the fourth day. Spinal blockade of CCK-A or CCK-B receptors blocked the development of tolera...Continue Reading

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Citations

Jun 24, 2014·Pain Management·Carol G T VanceKathleen A Sluka
May 5, 2011·Expert Review of Neurotherapeutics·Mark I Johnson, Jan M Bjordal
Mar 10, 2016·Journal of Physical Therapy Science·Eduardo José Nepomuceno MontenegroDaniella Araújo de Oliveira
Aug 4, 2012·The Journal of Pain : Official Journal of the American Pain Society·Karina L SatoKathleen A Sluka
Oct 11, 2011·Peptides·Richard J Bodnar
Feb 7, 2015·Neuromodulation : Journal of the International Neuromodulation Society·Gabriela R LaurettiAnita L Mattos
Dec 15, 2010·Pain·Richard E LiebanoKathleen A Sluka
Apr 11, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Shinsuke InoueKathleen A Sluka
Aug 25, 2018·Cephalalgia : an International Journal of Headache·Clinton G Lauritsen, Stephen D Silberstein
Feb 9, 2019·The Journal of Comparative Neurology·Maria Gutierrez-MecinasAndrew J Todd
Aug 29, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jennifer S GewandterNimish A Mohile
Sep 19, 2017·Molecular Neurobiology·Damien P Kuffler
Aug 11, 2018·Pflügers Archiv : European journal of physiology·Leidiane Mazzardo-MartinsDaniel Fernandes Martins
Dec 24, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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