PMID: 1196403Oct 15, 1975Paper

Choleresis and hepatic transport mechanisms. II. Influence of bile salt choleresis and biliary micelle binding on biliary excretion of various organic anions

Naunyn-Schmiedeberg's Archives of Pharmacology
R J VonkD K Meijer

Abstract

To investigate, whether binding to micelles has a function in hepatic transport, biliary excretion of three organic anions, phenolphthalein-beta-D-glucuronide (PG), dibromosulphthalein (DBSP) and indocyanine green (ICG) was studied in rats during saline, taurocholate or dehydrocholate administration. Taurocholate causes a weak choleresis with formation of biliary micelles, dehydrocholate a strong choleresis with little micelle formation. The two bile salts did not uniformly influence biliary excretion of the organic anions: biliary excretion of ICG (12.9 mumoles/kg) and DBSP (75.0 mumoles/kg) was stimulated by both bile salts: ICG excretion most pronounced by taurocholate and DBSP excretion most strongly by dehydrocholate. Biliary output of PG (25.8 and 200 mumoles/kg) was not stimulated by bile salt administration. Binding of PG, DBSP and ICG to biliary micelles was studied in sedimentation experiments by ultracentrifugation. PG, DBSP and ICG in bile showed a similar sedimentation pattern as 3H-taurocholate in bile, which indicates an association of all three anions with biliary micelles. Thus, the influence of bile salts on biliary transport of organic anions varies with the compound studied and the bile salt used, effects wh...Continue Reading

References

Jan 1, 1974·Investigative Radiology·R N BerkP M Loeb
Jul 1, 1974·The American Journal of Physiology·J L Barnhart, B Combes
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Oct 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·N B JAVITT

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Citations

Dec 23, 1976·The New England Journal of Medicine·N B Javitt
May 1, 1977·The American Journal of Physiology·J L MahuP Berthelot
Aug 1, 1987·Biochemical Pharmacology·A TakacsM Vore
Mar 30, 1982·Toxicology and Applied Pharmacology·Z Gregus, C D Klaassen
Nov 26, 2008·Gastroenterology·Frans J C CuperusHenkjan J Verkade

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