PMID: 702942Jun 1, 1978Paper

Choleretic properties of ursodeoxycholic acid and chenodeoxycholic acid in dogs

Japanese Journal of Pharmacology
S Yanaura, S Ishikawa

Abstract

Choleretic effects and properties of ursodeoxycholic and chenodeoxycholic acids given orally were investigated in comparison with dehydrocholic acid in conscious dogs with cholecystectomy. Ursodeoxycholic acid as well as chenodeoxycholic acid increased the bile flow and the concentrations of phospholipid, cholesterol and bile acids in the bile. After administration of either ursodeoxycholic acid or chenodeoxycholic acid, a great amount of each bile acid appeared in the bile. Ursodeoxycholic and chenodeoxycholic acids increased the outputs of phospholipid, cholesterol and bilirubin in the bile. On the other hand, dehydrocholic acid markedly decreased the concentrations and outputs of all the above materials in the bile, despite a considerable increase in the bile flow. After administration of dehydrocholic acid, 3alpha, 7alpha-dihydroxy-12-keto-cholanoic acid appeared in the bile instead of dehydrocholic acid. The results suggest that ursodeoxycholic and chenodeoxycholic acids are transported into the bile from the hepatic cells where they produce a choleresis due to the bile acid-dependent mechanism. Dehydrocholic acid is metabolized in the liver and the metabolites produced hydrocholeresis.

References

Sep 1, 1973·European Journal of Pharmacology·C D Klaassen
Jun 1, 1972·The Journal of Clinical Investigation·H O Wheeler, K K King
Nov 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·C D Klaassen
Aug 1, 1970·The American Journal of Physiology·S ErlingerM Dumont
Apr 1, 1968·The American Journal of Physiology·H O WheelerS E Bradley
Feb 1, 1969·The Journal of General Physiology·S AlpertI M Arias

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Citations

Sep 1, 1982·Digestive Diseases and Sciences·W H Bachrach, A F Hofmann
Jun 16, 2009·The Veterinary Clinics of North America. Small Animal Practice·Sharon A Center
Apr 20, 2004·Australian Veterinary Journal·L A AbrahamS A Holloway
May 7, 2021·Veterinary Medicine and Science·Fausto QuintavallaRoberto Ramoni
Aug 24, 1981·Biochimica Et Biophysica Acta·M ParquetR Infante
Oct 30, 2021·Journal of Veterinary Internal Medicine·Frederik AllanKatie E McCallum

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