PMID: 6411887Jan 1, 1983Paper

Cholestasis and total parenteral nutrition: in vivo studies on dogs

Journal of Pediatric Gastroenterology and Nutrition
I ZahaviE A Shaffer

Abstract

The effect of total parenteral nutrition (TPN) on bile formation was evaluated in 10 studies performed on three adult dogs. The bile duct was directly cannulated via a Thomas cannula while bile salt secretion was maintained by intravenous [14C]taurocholic acid infusion. After a 1.5-h basal period, either an amino acid solution (2.5% Travasol) with 10% glucose, or a lipid emulsion (10% Intralipid) was added intravenously for 2 h, followed by a second control period. The amino acid-glucose solution resulted in a significant (p less than 0.05) increase in bile flow which rose (+33%) while bile salt secretion increased transiently (+11%) and then returned to basal levels. The specific activity of taurocholate secreted did not decrease during the amino acid-glucose infusion, indicating that the unexpected increase in bile salt secretion was mainly due to a washout of the biliary tree rather than to enhanced synthesis. Cholesterol, phospholipid, and bilirubin outputs did not change significantly. Intralipid had no effect on bile flow or solute secretion. Thus, short-term TPN therapy with amino acids and glucose had no cholestatic effect in dogs, but rather produces a transient choleresis which is largely independent of bile salts.

Citations

Sep 1, 1989·Scandinavian Journal of Gastroenterology·O Mathisen, E Omland

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

JAMA : the Journal of the American Medical Association
D W Wilmore, S J Dudrick
Journal of Pediatric Gastroenterology and Nutrition
R J Merritt
The American Journal of Nursing
L Borgen
© 2021 Meta ULC. All rights reserved