Cholestasis of total parenteral nutrition: bile acid and bile lipid metabolism in parenterally nourished rats

Gastroenterology
F LirussiR H Dowling

Abstract

As food in the intestine "drives" the enterohepatic circulation and bile acids influence bile flow, we postulated that the cholestasis of total parenteral nutrition might be due to bile acid changes, and the cholelithiasis and biliary sludge of total parenteral nutrition to bile lipid changes. We therefore studied bile acid and bile lipid metabolism in the following groups of rats, with and without bile fistula: (a) nonfasted, orally fed controls, (b) orally fed controls fasted for 20 h, and (c) after 7 days of total parenteral nutrition. Biliary bile acid concentration (35.4 +/- 2.5 mM) and secretion (253 +/- 20.0 mumol/100 g body wt.24 h) increased significantly in the rats on TPN and the rats fasted for 20 h (38.8 +/- 2.5 and 243 +/- 23.4 mM, respectively) when compared with the orally fed controls (26.5 +/- 2.5 and 178 +/- 23.5 mM, respectively). Bile flow, however, was unchanged. Bile acid pool size (Eriksson washout technique) also increased from 43.4 +/- 3.0 mumol/100 g body wt in the controls to 50.5 +/- 4.8 in the group fasted for 20 h and 65.6 +/- 5.3 in the TPN group (p less than 0.05-0.01). Similar bile acid pool sizes (carcass extraction method) were found in the nonfistulated animals. Biliary cholesterol secretion...Continue Reading

Citations

Jul 21, 2000·Alimentary Pharmacology & Therapeutics·M Angelico, P Della Guardia
Feb 22, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Lucia CarulliMarco Bertolotti
Jul 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·L A LeaseburgeP R Schloerb
Dec 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C M St GeorgeE A Shaffer
Jun 1, 1995·Journal of the American College of Nutrition·E R Briones, F L Iber
Jun 15, 1997·Transplantation·F K Chan, E A Shaffer
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Mar 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·J M CulebrasJ Gonzalez-Gallego
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Dec 4, 2003·Best Practice & Research. Clinical Gastroenterology·Jeremy Mark Darby Nightingale
Sep 1, 1992·Metabolism: Clinical and Experimental·R H DowlingJ A Wass
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