Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis

Journal of Alzheimer's Disease : JAD
Hua-Long WangMing-Wei Wang

Abstract

Abnormal cholesterol metabolism is an established feature of Alzheimer's disease (AD). Cerebrospinal fluid (CSF) is the fluid surrounding the central nervous system, and the protein and lipid content alterations in the CSF could be biomarkers for degenerative changes in the brain. The laboratory diagnosis of AD is limited to the analysis of three biomarkers in CSF: Aβ42, total tau, and phospho-tau. The purpose of this analysis is to systematically analyze the available data describing the biomarkers of cholesterol and its metabolites in the CSF of subjects with AD. MEDLINE, EMBASE, and the Cochrane Central database were systematically queried to collect studies that have evaluated the markers of cholesterol and its metabolites in the CSF of subjects with mild cognitive impairment (MCI) or AD and age-matched controls. Analysis of the published data shows that the levels of cholesterol are increased in MCI subjects; 24-hydroxycholesterol and 27-hydroxycholesterol are elevated in AD and MCI subjects compared to controls. There is a significant dysfunction of cholesterol metabolism in the CSF of AD subjects. This analysis indicates that in addition to the available biomarkers in the CSF, such as Aβ42, total tau, and phospho-tau, 24...Continue Reading

References

Jan 5, 2002·Journal of Psychiatric Research·A PapassotiropoulosR Heun
Jul 24, 2002·Neurology·D A BennettJ Bach
Jan 1, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Frank W Pfrieger
Feb 26, 2003·Neurobiology of Aging·M Axel WollmerAndreas Papassotiropoulos
Mar 27, 2003·Nature Neuroscience·Luigi PuglielliDora M Kovacs
Apr 6, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Valerio LeoniIngemar Björkhem
Jan 13, 2006·Neuroscience Letters·Valerio LeoniLars-Olof Wahlund
Jul 27, 2006·Acta Neurologica Scandinavica. Supplementum·I BjörkhemU Diczfalusy
Jul 27, 2006·Acta Neurologica Scandinavica. Supplementum·B WolozinA McKee
Aug 6, 2008·Brain Research·Homeira QureischieHeike Kölsch
Feb 10, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·Valerio Leoni
Mar 17, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·Heike KölschReinhard Heun
Apr 21, 2009·Journal of Cellular and Molecular Medicine·Heike KölschReinhard Heun
Aug 4, 2009·Dementia and Geriatric Cognitive Disorders·Alina SolomonRachel A Whitmer
Aug 8, 2009·Journal of Alzheimer's Disease : JAD·Kaj Blennow, Henrik Zetterberg
Sep 29, 2009·Experimental Neurology·Ana Catarina R G FonsecaCláudia M F Pereira
Mar 17, 2010·Biochimica Et Biophysica Acta·Heike KölschDieter Lütjohann
May 27, 2010·PloS One·Juliet A MoncasterLee E Goldstein
Jun 29, 2010·Biochimica Et Biophysica Acta·M Axel Wollmer
Feb 8, 2011·Journal of Alzheimer's Disease : JAD·Laura MateosAngel Cedazo-Mínguez
May 19, 2011·Acta Psychiatrica Scandinavica·T VanmierloD Lütjohann
Jan 24, 2012·Alzheimer's Research & Therapy·Benjamin Wolozin
Oct 19, 2012·Journal of Alzheimer's Disease : JAD·Timothy M HughesLewis H Kuller
Jan 8, 2013·Biochemical Pharmacology·Julius PoppDieter Lütjohann
Apr 2, 2013·Biochemical Pharmacology·Valerio Leoni, Claudio Caccia
May 15, 2013·Journal of Alzheimer's Disease : JAD·Valerio LeoniIngemar Björkhem
Mar 26, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael EwersHarald Hampel
Jun 23, 2015·CNS Neuroscience & Therapeutics·Aydé Mendoza-OlivaClorinda Arias
Jul 5, 2015·Brain : a Journal of Neurology·Fathia DjeltiNathalie Cartier

❮ Previous
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Citations

Oct 30, 2016·Biochimie·Julie ColinThierry Oster
Jan 30, 2019·Diseases·Paloma Fernández-SanzVega García-Escudero
Aug 28, 2020·The European Journal of Neuroscience·Nikita Patil Samant, Girdhari Lal Gupta
Nov 2, 2017·Frontiers in Aging Neuroscience·Weicong RenMingwei Wang
Sep 19, 2019·Current Aging Science·Oliwia McFarlane, Kornelia Kędziora-Kornatowska
Jun 24, 2020·Brain Sciences·Olalla Sáiz-VazquezJavier Santabárbara
Apr 10, 2020·Neuronal Signaling·Thaddeus K WeigelHeather A Ferris
Feb 18, 2020·Journal of Alzheimer's Disease : JAD·Eleonora CipollariUNKNOWN Alzheimer’s Disease Metabolomics Consortium
Nov 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kai YangTaolei Sun
Sep 16, 2019·Revue neurologique·G C RománE Toledo
Jan 19, 2021·Curēus·Mehak Agarwal, Safeera Khan
Mar 8, 2021·Alzheimer's Research & Therapy·Anna Sandebring-MattonMiia Kivipelto
Apr 7, 2021·Molecular Psychiatry·Zeljka KoradeKároly Mirnics

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