Cholesterol 7 alpha-hydroxylase activity in hypothyroidism and hyperthyroidism in humans

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
G SauterR Hoermann

Abstract

Alterations of serum cholesterol levels are well recognized findings in hypothyroidism and hyperthyroidism. It remains unclear, whether thyroid hormones may affect serum concentrations of cholesterol through changes in the activity of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in the catabolic conversion of cholesterol to bile acids. We determined serum concentrations of the bile acid precursor 7 alpha-hydroxy-4-cholesten-3-one, which reflects cholesterol 7 alpha-hydroxylase activity in the liver, in 19 patients with hypothyroidism and in 10 patients with hyperthyroidism before and after treatment, respectively. In patients with hypothyroidism, serum concentrations of cholesterol and LDL-cholesterol decreased by 33% (p < 0.0005) and 39% (p < 0.0005), respectively, after replacement therapy with thyroid hormones. In contrast, serum concentrations of 7 alpha-hydroxy-4-cholesten-3-one (21.7 +/- 15.8 ng/ml vs 24.5 +/- 18.1 ng/ml before treatment, n.s.) as well as serum HDL-cholesterol were unchanged during substitution therapy. In patients with hyperthyroidism, serum concentrations of cholesterol and LDL-cholesterol increased by 27% (p < 0.01) and 39% (p < 0.01) after antithyroid treatment, respectively. Again, serum...Continue Reading

Citations

Mar 4, 2014·Molecular and Cellular Endocrinology·Jan A Lammel LindemannStephen D Ayers
Jul 27, 2011·Journal of Lipids·Melpomeni PeppaGeorge Dimitriadis
Feb 21, 2009·World Journal of Gastroenterology : WJG·Maria J MonteJose Vazquez-Tato
Aug 31, 2014·Journal of Lipid Research·Ylva BondeMats Rudling
Aug 29, 2006·World Journal of Gastroenterology : WJG·Ewa Cristine Siljevik Ellis
Jan 5, 2000·Physiological Reviews·G J Schroepfer

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