PMID: 2502006Jul 1, 1989Paper

Cholesterol and apolipoprotein distribution in plasma high-density-lipoprotein subclasses from zinc-deficient rats

The American Journal of Clinical Nutrition
S I Koo, C C Lee

Abstract

Effect of zinc deficiency on the composition of plasma high-density-lipoprotein (HDL) subclasses was investigated in adult male rats (ZD) fed a diet containing 2.8 micrograms of Zn/g as compared with pair-fed (PF) and ad libitum-fed (CT) controls given 30.8 micrograms of Zn/g. Three HDL subclasses were isolated by heparin-affinity chromatography: HDL containing no apo E (HDL-E0), HDL with a moderate amount of apo E (HDL-E1), and HDL highly enriched in apo E (HDL-E2). The plasma levels of total HDL cholesterol and protein were markedly decreased in ZD. The decreases were due primarily to a significant decline in circulating HDL-E0 particles. The percent content of free cholesterol in HDL-E2 was increased in ZD compared with PF and CT. Zn deficiency decreased the plasma concentrations of apo A-I and apo C of HDL-E0 and total apo E associated with HDL-E1 and HDL-E2. The mechanisms for such changes await further investigation.

Citations

Sep 14, 1999·The American Journal of Physiology·J Y WuK Y Lei
Aug 6, 2015·Nutrition & Metabolism·Priyanga RanasingheG R Constantine
Feb 1, 1992·Journal of the American College of Nutrition·J A HeG Q He
Jul 11, 2002·American Journal of Physiology. Cell Physiology·Libin CuiK Y Lei
Mar 13, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·L A RamadanO H El-Habit
Jan 1, 1996·Life Sciences·B Leininger-Muller, G Siest

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