Cholesterol and cognitive performance among community volunteers from the Czech Republic

International Psychogeriatrics
Marianne Chanti-KetterlJakub Hort

Abstract

Research shows that lipid levels may be associated with cognitive function, particularly among women. We aimed to examine total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein (HDL), and HDL/LDL ratio in relation to cognitive performance, measured with six well-established cognitive domains and a composite cognitive score (CCS). In this cross-sectional study, biomarkers and neuropsychological assessment were available for 141 adults with MMSE scores ≥ 24 (mean age = 69 years, 47% female, mean education = 14.4 years) attending a neuropsychological evaluation. Ordinary least squares regressions were adjusted for age, gender, education, and depressive symptoms in Model 1 and also for apolipoprotein E4 (APOE4) status in Model 2. High-density lipoprotein cholesterol (HDL-C) was associated with better CCS (β = 0.24; p = 0.014). This association was significant among women (β = 0.30; p = 0.026) and not among men (β = 0.20; p = 0.124). HDL-C was also related to attention/working memory (β = 0.24; p = 0.021), again only among women (β = 0.37; p = 0.012) and not men (β = 0.15; p = 0.271). Adjusting for APOE4 yielded significance for high HDL-C and CCS (β = 0.24; p = 0.022). HDL-...Continue Reading

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Citations

Dec 15, 2015·Neuropsychologia·Maria Stefania De SimoneGiovanni Augusto Carlesimo
Nov 2, 2016·Journal of Alzheimer's Disease : JAD·Martina PařízkováJan Laczó
Nov 27, 2018·Journal of Alzheimer's Disease : JAD·Colleen PappasJakub Hort
Oct 5, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marianne Chanti-KetterlYang Claire Yang

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