Cholesterol and the activity of bacterial toxins

FEMS Microbiology Letters
M Palmer

Abstract

Cholesterol may affect the activity of microbial toxins in a direct, specific way, or it may exert indirect effects because of its role in membrane fluidity, membrane line tension, and in the stabilization of rafts in the cytoplasmic membrane. The thiol-activated toxins of gram-positive bacteria, and the cytolysin of Vibrio cholerae are presented as examples of specific toxin-cholesterol interaction. Several mechanisms of indirect effects of cholesterol are discussed using examples such as Staphylococcus aureus alpha-hemolysin, aerolysin, and diphtheria toxin.

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Citations

Feb 8, 2007·Archives of Microbiology·Hong-Nu YuJong-Suk Kim
Oct 5, 2010·The Journal of Biological Chemistry·Tilen PraperRobert J C Gilbert
Nov 10, 2009·Journal of Bacteriology·Takashige KashimotoNobuyuki Susa
Mar 15, 2006·Trends in Microbiology·Mickaël DesvauxMark J Pallen
Dec 13, 2005·Biophysical Journal·Harpreet Singh, Richard H Ashley
Mar 12, 2015·Journal of Chemical Information and Modeling·Nan LiuLeslie A Kuhn
Apr 15, 2015·Advanced Drug Delivery Reviews·Ronnie H FangLiangfang Zhang
Apr 22, 2008·Biochimica Et Biophysica Acta·Richard M Epand
Apr 17, 2016·Progress in Lipid Research·Francisco J Barrantes, Jacques Fantini
Jul 1, 2016·Journal of Pharmaceutical and Biomedical Analysis·Atsushi ShojiMasao Sugawara
Mar 21, 2015·Biochimica Et Biophysica Acta·Michael Stangl, Dirk Schneider
Nov 3, 2010·IEEE Transactions on Visualization and Computer Graphics·Kai Pöthkow, Hans-Christian Hege
Apr 7, 2007·Academic Medicine : Journal of the Association of American Medical Colleges·Debra K Litzelman, Ann H Cottingham
Mar 10, 2018·Cellular and Molecular Life Sciences : CMLS·Garima JaipuriaMarkus Zweckstetter

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