PMID: 7503299Nov 1, 1995

Cholesterol content of trout plasma membranes varies with acclimation temperature

The American Journal of Physiology
J C Robertson, J R Hazel

Abstract

Involvement of cholesterol in thermally induced restructuring of biological membranes was investigated in several tissues of rainbow trout (Oncorhynchus mykiss). Cholesterol-rich plasma membranes (PM) were isolated from erythrocytes, liver, kidney, and gill of fish acclimated to 5 and 20 degrees C. Mean PM cholesterol-to-phospholipid molar ratios (C/P) from warm-acclimated animals were significantly higher than those of cold-acclimated fish in liver (0.26 vs. 0.18; P < 0.01), kidney (0.49 vs. 0.40; P < 0.02), and gill (0.66 vs. 0.60; P < 0.05); erythrocyte C/P did not differ significantly with acclimation temperature (0.28 vs. 0.25; P = 0.25). In light of the ordering effects of cholesterol on fluid-phase membranes, these results are consistent with a role for cholesterol in the homeoviscous response of some poikilotherm PMs. Tissue differences in both PM cholesterol levels and the magnitude of thermally evoked cholesterol changes may reflect tissue-specific membrane functions. Lower PM C/P of trout tissues relative to corresponding data available for homeotherms also support a possible evolutionary relationship between cholesterol content and thermal adaptation of the PM.

Citations

Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D PadrónJ R Hazel
Nov 11, 2014·Functional Ecology·Brandon S CooperKristi L Montooth
Feb 29, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Reijo KäkeläMatti Vornanen
Dec 29, 2020·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Paul L Else

Related Concepts

Acclimatization
Plasma Membrane
Epicholesterol
High Pressure Liquid Chromatography Procedure
Membrane Lipids
Phospholipids
Cabeza Acerada

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