PMID: 16502619Mar 1, 2006Paper

Cholesterol crystals rupture biological membranes and human plaques during acute cardiovascular events--a novel insight into plaque rupture by scanning electron microscopy

Scanning
George S Abela, Kusai S Aziz

Abstract

Plaque rupture and/or erosion are considered the leading cause of cardiovascular events. To elucidate this process, we demonstrated that during cholesterol crystallization the occupied volume increases rapidly and sharp-tipped crystals cut through thin biological membranes in their path. The amount of cholesterol correlated directly with both peak level and rate of crystal growth (r = 0.98; r = 0.99; p < 0.01, respectively). These observations suggest that crystallization of cholesterol in atherosclerotic plaques can induce cap rupture and/or erosion. Observations by scanning electron microscopy confirmed similar findings of cholesterol crystals perforating the lumen surface in human coronary artery segments with ruptured plaque.

References

Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A M HenneyS Humphries
Apr 1, 1991·Journal of the American College of Cardiology·J H Qiao, M C Fishbein
Mar 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D M Small
May 1, 1997·The New England Journal of Medicine·A P BurkeR Virmani
Mar 26, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·G Kellner-WeibelG H Rothblat
Aug 14, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·G Kellner-WeibelG H Rothblat
May 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R VirmaniS M Schwartz
Sep 28, 2000·The New England Journal of Medicine·J A GoldsteinW W O'Neill
Jun 14, 2002·Cardiovascular Research·Mark D Rekhter
Feb 22, 2005·International Journal of Cardiology·Viktor CulićDinko Mirić

❮ Previous
Next ❯

Citations

Jun 21, 2006·Journal of Thrombosis and Thrombolysis·Hongbao MaGeorge S Abela
Apr 19, 2012·Journal of the American Chemical Society·Lucie RoutaboulBernard Doudin
Mar 15, 2011·European Heart Journal·Jean-Baptiste MichelGerard Pasterkamp
Jan 15, 2009·Journal of Lipid Research·Alkystis PhinikaridouJames A Hamilton
Jan 16, 2014·Current Atherosclerosis Reports·Stefan M NidorfPeter L Thompson
Feb 16, 2013·Current Rheumatology Reports·Alena Grebe, Eicke Latz
Aug 30, 2012·Journal of Cardiovascular Medicine·Jean-Baptiste MichelJosé L Martin-Ventura
Oct 12, 2011·Expert Review of Cardiovascular Therapy·Majid M MughalGeorge S Abela
Apr 12, 2008·Expert Review of Cardiovascular Therapy·Fadi ShamounGeorge Abela
Aug 27, 2013·Clinical Therapeutics·Peter L ThompsonJohn Eikelboom
Dec 26, 2015·European Heart Journal·Abed JanoudiGeorge S Abela
Nov 13, 2009·International Journal of Cardiology·Dimitrios N TziakasHarisios Boudoulas
Sep 19, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Xin ShiPeng Qu
Aug 19, 2015·Microscopy Research and Technique·Mojdeh NasiriGeorge S Abela
Jul 17, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Giuseppe M SangiorgiGiusseppe Biondi-Zoccai
Apr 13, 2011·European Journal of Immunology·Stefan FreigangManfred Kopf
Apr 22, 2011·The American Journal of Cardiology·George S AbelaUmesh Tamhane
May 21, 2011·JACC. Cardiovascular Interventions·Nitesh GadeelaGeorge S Abela
Apr 25, 2016·Current Atherosclerosis Reports·Nicholas R EvansJames H F Rudd
Mar 19, 2011·Journal of the American College of Cardiology·Johanne SilvainJohn W Weisel
Aug 16, 2008·Atherosclerosis·Ameeth VedreGeorge S Abela
Jul 31, 2013·American Journal of Clinical Pathology·Michael Van NessPaul Holland
Aug 1, 2013·Physiological Reviews·Paul N Hopkins
Jul 3, 2020·Journal of the American Heart Association·Osamu KuriharaIk-Kyung Jang
Sep 17, 2013·Journal of Cardiovascular Pharmacology and Therapeutics·Stefan M NidorfPeter L Thompson
Mar 17, 2017·F1000Research·Michael D Shapiro, Sergio Fazio
Dec 28, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Serena FragiottaK Bailey Freund
Apr 20, 2016·Current Atherosclerosis Reports·Oliver G AbelaGeorge S Abela
Dec 29, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Christopher HalkiasPaul F A Wright
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·David S SchadeR Philip Eaton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.