Cholesterol ester accumulation: an immediate consequence of acute in vivo ischemic renal injury

Kidney International
R A ZagerSamuel D Wright

Abstract

Cholesterol is a major constituent of plasma membranes, and recent evidence indicates that it is up-regulated during the maintenance phase of acute renal failure (ARF). However, cholesterol's fate and that of the cholesterol ester (CE) cycle [shuttling between free cholesterol (FC) and CEs] during the induction phase of ARF have not been well defined. The present studies sought to provide initial insights into these issues. FC and CE were measured in mouse renal cortex after in vivo ischemia (15 and 45 minutes)/reperfusion (0 to 120 minutes) and glycerol-induced myoglobinuria (1 to 2 hours). FC/CE were also measured in (1) cultured human proximal tubule (HK-2) cells three hours after ATP depletion and in (2) isolated mouse proximal tubule segments (PTSs) subjected to plasma membrane damage (with cholesterol oxidase, sphingomyelinase, phospholipase A2, or cytoskeletal disruption with cytochalasin B). The impact of cholesterol synthesis inhibition (with mevastatin) and FC traffic blockade (with progesterone) on injury-evoked FC/CE changes was also assessed. In vivo ischemia caused approximately threefold to fourfold CE elevations, but not FC elevations, that persisted for at least two hours of reperfusion. Conversely, myoglobinur...Continue Reading

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Citations

Aug 7, 2002·The American Journal of Pathology·Richard A ZagerSherry Hanson
Feb 4, 2011·Expert Reviews in Molecular Medicine·Stephen M ColganRichard C Austin
Apr 23, 2002·Kidney International·Richard A ZagerVivian dela Rosa
Sep 15, 2007·Critical Care Medicine·Christoph SchmidtMichael Bucher
Jan 25, 2005·Nephrology·Christine PercyGlenda Gobé
Sep 22, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Lawrence G PessolanoBarbara M Schreiber
Jul 30, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Ali Cm JohnsonRichard A Zager
Jan 23, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Paul JenningsTara McMorrow
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Katherine R TuttleConnie L Davis
Aug 4, 2001·The American Journal of Pathology·R A ZagerW M Bennett
Oct 18, 2018·American Journal of Physiology. Renal Physiology·Pauline ErpicumFrançois Jouret
May 11, 2012·American Journal of Physiology. Renal Physiology·Sárka LhotákRichard C Austin
Sep 4, 2003·American Journal of Physiology. Renal Physiology·Richard A ZagerSherry Y Hanson
Jan 1, 2003·The American Journal of Pathology·Ali C M JohnsonRichard A Zager
Jun 24, 2003·The American Journal of Pathology·Richard A ZagerVallabh O Shah

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