Cholesterol Extraction from Cell Membrane by Graphene Nanosheets: A Computational Study

The Journal of Physical Chemistry. B
Liuyang ZhangXianqiao Wang

Abstract

The health risk associated with high cholesterol levels in the human body has motivated intensive efforts to lower them by using specialized drugs. However, little research has been reported on utilizing nanomaterials to extract extra cholesterol from living tissues. Graphene possesses great potential for cholesterol extraction from cell membranes due to its distinct porous structure and outstanding surface adhesion. Here we employ dissipative dynamic simulations to explore pathways for cholesterol extraction from a cell membrane by a sheet of graphene using a coarse-grained graphene nanosheets (CGGN) model. We first demonstrate that the self-assembly process among a single layer of graphene and a group of randomly distributed cholesterol molecules in the aqueous environment, which provides a firm foundation for graphene-cholesterol interactions and the dynamic cholesterol extraction process from the cell membrane. Simulations results show that graphene is capable of removing cholesterol molecules from the bilayer membrane. The interaction between graphene and cholesterol molecules plays an important role in determining the amount of extracted cholesterol molecules from the cell membrane. Our findings open up a promising avenue...Continue Reading

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Citations

Jun 30, 2016·Physical Chemistry Chemical Physics : PCCP·Tongtao YueFang Huang
Nov 15, 2018·International Journal of Molecular Sciences·Chengzhu LiaoSie Chin Tjong
Feb 25, 2018·Nature Communications·Kristina E KitkoQi Zhang
Jun 6, 2019·Beilstein Journal of Nanotechnology·Qura Tul AinMuhammad Naeem Anjum
Jun 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pengyu Chen, Li-Tang Yan
Nov 1, 2018·Advanced Materials·Qi XinJian Ru Gong
Jan 1, 2016·Nanomaterials·Liuyang Zhang, Xianqiao Wang
Feb 16, 2021·Frontiers in Bioengineering and Biotechnology·João SantosAndrea Capasso
Jul 8, 2020·The Journal of Physical Chemistry. B·Przemysław RaczyńskiZbigniew Dendzik
Aug 14, 2019·The Journal of Physical Chemistry. B·Timothy C MooreClare McCabe
Apr 9, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Yonghui ZhangJun Fan
Jul 19, 2017·ACS Applied Materials & Interfaces·Liuyang ZhangXianqiao Wang
Nov 25, 2021·ACS Applied Materials & Interfaces·Priya MandalSajal K Ghosh

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