Cholesterol induced CTAB micelle-to-vesicle phase transitions

Journal of Colloid and Interface Science
Mary Cano-SarabiaJaume Veciana

Abstract

Vesicles prepared by self-assembly of a hydrated mixture of a cationic surfactant (cetyltrimethylammonium bromide) and a lipid (cholesterol) are studied as potential nanocarriers for the delivery of active ingredients. The understanding of the mechanism of the micelle-to-vesicle transition involved in the vesicle formation appears to be crucial regarding the stability of the vesicles as nanovectors. Here, UV-Vis spectroscopy is used to monitor the phase transition from micelles to vesicles promoted by the progressive addition of cholesterol to CTAB micellar solutions. The employed solvatochromic indicator, pinacyanol chloride (PIN), is a cyanine dye that is highly sensitive to the polarity of the medium. The self-assembly between the CTAB and the cholesterol molecules is investigated by means of turbidity (optical density) measurements as well.

References

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Jan 31, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Mary Cano-SarabiaJaume Veciana
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Citations

Jun 20, 2013·Journal of Colloid and Interface Science·Mikhail A VoroninAlexander I Konovalov
Jun 26, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Marianne LiebiErich J Windhab
May 8, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Lidia Ferrer-TasiesJaume Veciana
Aug 31, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Zhong-Kai CuiMichel Lafleur
Oct 11, 2016·Chemical Society Reviews·N GrimaldiN Ventosa
Oct 21, 2016·Journal of Microencapsulation·Xunan ZhangXiaojun Han
Feb 1, 2017·Drug and Chemical Toxicology·Faqir MuhammadSantosh Aryal
Jan 11, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Sargam M RajputSuresh Kumar Kailasa
Oct 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yiyin ChenAihua Zou

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