Cholesterol-induced stimulation of platelet aggregation is prevented by a hempseed-enriched diet

Canadian Journal of Physiology and Pharmacology
M A ProciukGrant N Pierce

Abstract

Hypercholesterolemia indirectly increases the risk for myocardial infarction by enhancing the ability of platelets to aggregate. Diets enriched with polyunsaturated fatty acids (PUFAs) have been shown to reduce the detrimental effects of cholesterol on platelet aggregation. This study investigated whether dietary hempseed, a rich source of PUFAs, inhibits platelet aggregation under normal and hypercholesterolemic conditions. Male New Zealand white rabbits were fed one of 6 dietary interventions: regular control diet (RG); control diet + 10% hempseed (HP); control diet + 10% partially delipidated hempseed (DHP); control diet + 0.5% cholesterol (OL); control diet + 0.5% cholesterol + 10% hempseed (OLHP); control diet + 5% coconut oil (CO). After 8 weeks, blood was collected to measure ADP- and collagen-induced platelet aggregation and plasma levels of fatty acids, cholesterol, and triglycerides. The hempseed-fed animals (HP and OLHP) displayed elevated plasma levels of PUFAs and a prominent enhancement in 18:3n-6 (gamma-linolenic acid, GLA) levels, a unique PUFA found in hempseed. The cholesterol-supplemented groups (OL and OLHP) had significantly elevated plasma levels of cholesterol and triglycerides, but platelet aggregation w...Continue Reading

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Citations

Feb 3, 2011·Journal of Physiology and Biochemistry·Vishal SinghManoj Kumar Barthwal
Apr 23, 2010·Nutrition & Metabolism·Delfin Rodriguez-Leyva, Grant N Pierce
Dec 23, 2015·International Journal of Molecular Sciences·Ian James Martins
Jun 15, 2016·Pediatric Emergency Care·Matteo ChinelloMauro Calvani
Apr 15, 2016·Phytotherapy Research : PTR·Antonella SmeriglioClara Circosta
Jan 26, 2011·Journal of Thrombosis and Haemostasis : JTH·B NagyS P Kunapuli
Sep 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·H P Vasantha RupasingheValtcho D Zheljazkov
Dec 16, 2020·Comprehensive Reviews in Food Science and Food Safety·William LeonardZhongxiang Fang
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Nov 4, 2017·Journal of Agricultural and Food Chemistry·Gilda AielloAnna Arnoldi
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Sep 22, 2017·Journal of Agricultural and Food Chemistry·Chiara ZanoniCarmen Lammi
Jan 19, 2018·The Journal of Organic Chemistry·Guo-Yuan ZhuZhi-Hong Jiang

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