Cholesterol kinetics in subjects with bile fistula. Positive relationship between size of the bile acid precursor pool and bile acid synthetic rate

The Journal of Clinical Investigation
C C SchwartzPatricia S Cooper

Abstract

Our aim was to identify and quantitate cholesterol pools and transport pathways in blood and liver. By studying bile fistula subjects, using several types of isotopic preparations, simultaneous labeling of separate cholesterol pools and sampling all components of blood and bile at frequent intervals, we developed a comprehensive multicompartmental model for cholesterol within the rapidly miscible pool. Data in six components (bile acids, esterified cholesterol in whole plasma, and free cholesterol in blood cells, bile, alpha lipoproteins, and beta lipoproteins) were modeled simultaneously with the SAAM program. The analysis revealed extensive exchange of free cholesterol between HDL and liver, blood cells, and other tissues. There was net free cholesterol transport from HDL to the liver in most subjects. The major organ that removed esterified cholesterol from blood was the liver. A large portion (4,211 mumol) of total hepatic cholesterol comprised a pool that turned over rapidly (t1/2 of 72 min) by exchanging mainly with plasma HDL and was the major source of bile acids and biliary cholesterol. Only 6% of hepatic newly synthesized cholesterol was used directly for bile acid synthesis: the analysis showed that 94% of newly synt...Continue Reading

References

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Citations

Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·M IkemotoK Inoue
Oct 2, 2013·Journal of Clinical Lipidology·Peter P TothDaniel J Rader
Dec 24, 2013·Current Opinion in Lipidology·Marc Hellerstein, Scott Turner
Dec 8, 2016·European Journal of Gastroenterology & Hepatology·Jiantao WangXiubo Jiang
Apr 9, 2014·Journal of Lipid Research·Luís M B B EstroncaWinchil L C Vaz
May 18, 2004·Journal of Lipid Research·Charles C SchwartzPatricia S Cooper
May 8, 2013·Journal of Lipid Research·Adriaan G HolleboomErik S G Stroes
Feb 9, 2017·Journal of Lipid Research·Marina CuchelDaniel J Rader
Apr 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·W R FisherP W Stacpoole
Apr 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P J JonesG L Namchuk
Jun 17, 1999·Alcoholism, Clinical and Experimental Research·M F LeitzmannE B Rimm
Nov 28, 2017·Current Opinion in Lipidology·John S Millar, Marina Cuchel
Jul 30, 2003·The American Journal of Clinical Nutrition·Michael F LeitzmannEdward L Giovannucci
Oct 13, 2019·Atherosclerosis·Markus AxmannHerbert Stangl
Dec 1, 1996·The American Journal of Physiology·R D ShamburekC C Schwartz

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