Cholesterol-lowering effect of Lactobacillus rhamnosus BFE5264 and its influence on the gut microbiome and propionate level in a murine model

PloS One
Soyoung ParkYosep Ji

Abstract

Thanks to recent scientific progress a relationship between the intestinal microbiota and metabolic diseases could be established. A deeper understanding of underlying mechanisms has opened ways towards new approaches for alleviating conditions associated with metabolic diseases. Dysbiosis appears to be a major underlying factor associated with metabolic syndrome and related adverse health conditions. A major focus has therefore shifted to controlling of the gut microbiota through administration of functional lactic acid bacteria (LAB). The scope for health promotion and/or support by probiotics such as LAB has thereby been widened beyond the improving of intestinal health, also to include anti-obesity, anti-diabetic and cholesterol-lowering effects. In this study we investigated the cholesterol-lowering and microbiota modulatory potential of a LAB strain, Lactobacillus rhamnosus BFE5264, isolated from Maasai fermented milk. A mouse model receiving a high-cholesterol diet served as model for evaluating its functionality. The administration of L. rhamnosus BFE5264 resulted in a significant reduction of the serum cholesterol level that was accompanied by changes in intestinal microbiota and the production of short chain fatty aci...Continue Reading

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Citations

May 1, 2020·Bioscience Reports·Bo ZhangChunsheng Li
May 28, 2020·Journal of Human Hypertension·Fernanda S ThomazMarloes Dekker Nitert
Apr 28, 2021·Probiotics and Antimicrobial Proteins·K S YohaC Anandharamakrishnan
Oct 15, 2021·Probiotics and Antimicrobial Proteins·Hongsup YoonWilhelm H Holzapfel
Jan 19, 2022·Tropical Animal Health and Production·Sofia SandiAsep I M Ali

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Datasets Mentioned

BETA
PRJNA412298

Methods Mentioned

BETA
PCR

Software Mentioned

Qiime
fastq
UCLUST
SPSS Statistics
Macqiime

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