Cholesterol lowering in pigs through enhanced bacterial bile salt hydrolase activity

The British Journal of Nutrition
I De SmetW Verstraete

Abstract

The effect of feeding live Lactobacillus reuteri cells containing active bile salt hydrolase (BSH) on plasma cholesterol levels was studied in pigs. During an experiment lasting 13 weeks, twenty pigs were fed on a high-fat, high-cholesterol, low-fibre for the first 10 weeks, and a regular pig diet for the last 3 weeks. One group of animals received, twice daily, 11.25 (SD 0.16) log10 colony forming units of the potential probiotic bacteria for 4 weeks (from week 3 until week 7). From week 8 onwards, the treated group was again fed on the same diet as the control group without additions. The total faecal Lactobacillus counts were only significantly higher in the treated pigs during the first 2 weeks of L reuteri feeding. Based on limited data, it was suggested that the administered Lactobacillus species had caused a temporary shift within the indigenous Lactobacillus population rather than permanently colonizing the intestinal tract. The probiotic feeding brought about significant lowering (P < or = 0.05) of total and LDL-cholesterol concentrations in the treated pigs compared with the control pigs, while no change in HDL-cholesterol concentration was observed. The data for faecal output of neutral sterols and bile salts were hi...Continue Reading

References

Jan 1, 1977·Acta Medica Scandinavica·B E GustafssonB Carlstedt-Duke
Apr 15, 1975·International Journal of Cancer. Journal International Du Cancer·B Armstrong, R Doll
Apr 1, 1989·Journal of Animal Science·A D DanielsonM A Amer
Jan 1, 1989·Scandinavian Journal of Psychology·U Stabell, B Stabell
Jan 1, 1989·Applied and Environmental Microbiology·M P Dashkevicz, S D Feighner
Dec 1, 1987·The American Journal of Clinical Nutrition·A van FaassenR J Hermus
Jan 1, 1987·Annual Review of Nutrition·E R Miller, D E Ullrey
Jan 1, 1986·Methods in Enzymology·M J Chapman
Jan 1, 1986·Journal of Steroid Biochemistry·R W OwenM J Hill
Sep 1, 1985·Zeitschrift für Ernährungswissenschaft·K E ScholzC A Barth
Sep 1, 1974·Lipids·J DupontD J Clow
Oct 1, 1972·Archives of Internal Medicine·S M Grundy
Jan 1, 1971·Atherosclerosis·H L Ratcliffe, H Luginbühl
May 1, 1969·Gut·V AriesR E Williams
Aug 1, 1980·Experimental and Molecular Pathology·D N KimW A Thomas
Nov 1, 1981·Digestive Diseases and Sciences·M B JonesG L Gitnick
Jul 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F M NagengastI P van Munster
May 1, 1995·The British Journal of Nutrition·M Fukushima, M Nakano
Sep 1, 1994·Applied and Environmental Microbiology·G W TannockM A McConnell
Sep 1, 1993·FEMS Microbiology Reviews·P Marteau, J C Rambaud

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Citations

Jul 23, 2013·Applied Microbiology and Biotechnology·Alessandra BordoniMaddalena Rossi
May 23, 2009·Journal of Medicinal Food·Indu Pal KaurKanwaljit Chopra
Jun 1, 2000·Applied and Environmental Microbiology·H TanakaI Mierau
Sep 4, 2004·Applied and Environmental Microbiology·Geun-Bae KimByong H Lee
Mar 7, 2006·Applied and Environmental Microbiology·Máire BegleyCormac G M Gahan
Dec 13, 2012·Lipids in Health and Disease·Immaculata Oyeyemi BanjokoAnthony Alaba Bakare
Jan 16, 2013·Advances in Nutrition·Lee R Hagey, Matthew D Krasowski
Jan 1, 2008·Interdisciplinary Perspectives on Infectious Diseases·Paul W O'Toole, Jakki C Cooney
Aug 23, 2008·Applied Microbiology and Biotechnology·Christopher MartoniSatya Prakash
Apr 18, 2014·Journal of Immunotoxicology·Jalila Ben Salah-AbbèsRidha Oueslati
Mar 4, 2005·Scandinavian Journal of Gastroenterology·P LepercqC Juste
May 23, 2012·Experimental Diabetes Research·Manoj KumarHariom Yadav
Jul 19, 2011·International Journal of Food Microbiology·D A RussellC Stanton
Nov 19, 2015·Journal of Clinical Pathology·Alessandro Di CerboTommaso Iannitti
May 27, 2005·Journal of Applied Microbiology·S C LeahyD van Sinderen
May 23, 2007·Molecular Systems Biology·François-Pierre J MartinJeremy K Nicholson
Feb 15, 2008·Journal of Biomedicine & Biotechnology·Christopher MartoniSatya Prakash
Aug 17, 2005·FEMS Microbiology Reviews·Máire BegleyColin Hill
Dec 3, 2014·Jornal de pediatria·Yvan VandenplasGeorges Daube
Dec 12, 2001·Letters in Applied Microbiology·P De BoeverW Verstraete
Nov 22, 2005·Journal of Lipid Research·Jason M RidlonPhillip B Hylemon
Jun 13, 2017·Molecular Aspects of Medicine·Sarah L LongSusan A Joyce
Sep 6, 2012·International Journal of Molecular Sciences·Motoi TamuraHiroyuki Nakagawa
Jan 27, 2016·Nature Communications·Katri KorpelaWillem M de Vos

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