Cholesterol metabolism and embryogenesis

Trends in Genetics : TIG
R V Farese, J Herz

Abstract

Although cholesterol has long been known to be an essential component of cell membranes in vertebrate organisms, recent studies have suggested that cholesterol plays a crucial role in specific processes during embryonic development, including the covalent modification of Hedgehog proteins. Here we review the overlapping developmental phenotypes associated with pharmacologically or genetically induced defects in cholesterol biosynthesis, embryonic cholesterol transport and Hedgehog proteins. Shared aspects of these phenotypes suggest that common mechanisms underlie impaired central nervous system development associated with cholesterol deficiency.

References

Aug 1, 1977·American Journal of Obstetrics and Gynecology·D S LinW E Connor
Jan 12, 1991·JAMA : the Journal of the American Medical Association·R W MahleyS C Rall
Nov 1, 1990·Circulation·S G Young
Apr 4, 1986·Science·M S Brown, J L Goldstein
Oct 1, 1972·The Journal of Clinical Investigation·R M PitkinD S Lin
Jan 1, 1967·Acta Anatomica·K Verma, D Wei King
Sep 1, 1980·Metabolism: Clinical and Experimental·K R FeingoldM D Siperstein
Jan 1, 1982·Developmental Biology·H P Pratt
Apr 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G ZhengR T McCluskey
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·P K FrykmanJ Herz
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·R V FareseS G Young
Sep 10, 1994·Annals of the New York Academy of Sciences·J Herz, T E Willnow
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G E HomanicsN Maeda
Aug 10, 1996·Lancet·P ClaytonD FitzPatrick
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·T E WillnowJ Herz
May 1, 1996·The Journal of Emergency Medicine·J A WoodsR F Edlich
Nov 1, 1996·Nature Genetics·E RoesslerM Muenke
Jan 1, 1997·Trends in Genetics : TIG·M HammerschmidtA P McMahon

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Citations

Feb 9, 2002·Molecular Reproduction and Development·Yhong-Hee ShimYoung-Ki Paik
Mar 24, 1999·Trends in Neurosciences·M Dubois-DalcqP Aubourg
Dec 3, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·J Frézal
Feb 17, 2001·Current Opinion in Neurobiology·B W Howell, J Herz
Jun 20, 2001·Trends in Cardiovascular Medicine·J L Barth, W S Argraves
Jul 18, 2002·Clinical Genetics·H R Waterham
Dec 21, 2000·International Journal of Dermatology·E A DiPretaH Skelton
May 6, 2003·Reproduction, Fertility, and Development·Debora SinnerElida Gonzalez
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·S M HammadW S Argraves
May 18, 1999·Current Opinion in Lipidology·B U FitzkyF F Moebius
Apr 29, 2000·Current Opinion in Lipidology·S K Moestrup, R Kozyraki
Apr 29, 2000·Current Opinion in Lipidology·J HerzT E Willnow
May 16, 2001·Current Opinion in Lipidology·L A Woollett
Aug 3, 2004·Journal of Medical Genetics·M Witsch-BaumgartnerG Utermann
Jun 5, 2002·Annual Review of Biochemistry·Joachim Herz, Hans H Bock
Mar 9, 2000·Trends in Endocrinology and Metabolism : TEM·F F MoebiusH Glossmann
Sep 17, 2013·Biochimica Et Biophysica Acta·Javier CañuetoRogelio González-Sarmiento
Aug 22, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Francesca TrinchellaRosaria Scudiero
Apr 26, 2003·Traffic·Petra May, Joachim Herz
May 27, 2008·Journal of Neuroscience Research·Carolina ParadaDavid Bueno
Mar 8, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·C GentiliF Descalzi Cancedda
Nov 22, 2005·Molecular and Cellular Endocrinology·Dayami Lopez, Mark P McLean
Jul 31, 1998·American Journal of Human Genetics·H R WaterhamR J Wanders
Jan 29, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Aspasia TsezouTheodora Simopoulou
Dec 6, 2001·The Journal of Clinical Investigation·H E MiettinenM Krieger
Oct 23, 2009·Plant Signaling & Behavior·David Posé, Miguel A Botella
Mar 22, 2003·Biochimica Et Biophysica Acta·Frank W Pfrieger
Oct 21, 2016·Plant Signaling & Behavior·Xia Zhang, Heping Li
Jun 11, 2002·International Journal of Toxicology·M MirshahiM K Agarwal
Apr 5, 2002·American Journal of Medical Genetics·M Michael Cohen, Kohei Shiota
Oct 14, 2003·American Journal of Medical Genetics. Part a·M Michael Cohen
Sep 8, 2004·Journal of Cellular Biochemistry·Irena ShurDafna Benayahu
Jul 30, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·George R LankasL David Wise

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