Cholesterol metabolism and therapeutic targets: rationale for targeting multiple metabolic pathways

Clinical Cardiology
S D Turley

Abstract

The liver is the major regulator of the plasma low density lipoprotein cholesterol (LDL-C) concentration because it is not only the site of formation of very low density lipoproteins (VLDL), the precursors of most LDL in the circulation, but it is also the organ where the bulk of receptor-mediated clearance of LDL takes place. The liver also initially clears all the cholesterol that is absorbed from the small intestine. The absorption of excess cholesterol can potentially increase the amount of cholesterol stored in the liver. This, in turn, can result in increased VLDL secretion, and hence LDL formation, and also downregulation of hepatic LDL receptor activity. Such events will potentially increase plasma LDL-C levels. The converse situation occurs when cholesterol absorption is inhibited. Cholesterol enters the lumen of the small intestine principally from bile and diet. The major steps involved in the absorption process have been characterized. On average, about half of all cholesterol entering the intestine is absorbed, but the fractional absorption rate varies greatly among individuals. While the basis for this variability is not understood, it may partly explain why some patients respond poorly or not at all to statins an...Continue Reading

References

Oct 1, 1979·Metabolism: Clinical and Experimental·J R Crouse, S M Grundy
Feb 1, 1975·Metabolism: Clinical and Experimental·P J NestelL J Cook
Oct 1, 1987·European Journal of Clinical Investigation·Y A Kesäniemi, T A Miettinen
Sep 1, 1986·The American Journal of Clinical Nutrition·E R BrionesB A Kottke
Jan 1, 1983·Annual Review of Nutrition·S M Grundy
Jan 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·Y A Kesäniemi, S M Grundy
Jul 1, 1982·Metabolism: Clinical and Experimental·J R CrouseJ H Johnson
Oct 12, 2001·Obesity Research·B MittendorferS Klein
Oct 13, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·R A RajaratnamT A Miettinen
Jan 5, 2002·Current Atherosclerosis Reports·Donald M Black
Oct 9, 2002·Circulation·Thomas SudhopKlaus von Bergmann
Oct 25, 2002·Drugs·Thomas Sudhop, Klaus von Bergmann
Nov 9, 2002·The American Journal of Cardiology·Claude GagnéUNKNOWN Ezetimibe Study Group
Nov 9, 2002·The American Journal of Cardiology·Scott M Grundy
Dec 31, 2002·Journal of the American College of Cardiology·Michael H DavidsonEnrico P Veltri
Apr 8, 2003·The American Journal of Cardiology·Henry N Ginsberg
Jul 4, 2003·Current Opinion in Lipidology·Stephen D Turley, John M Dietschy
Aug 13, 2003·Mayo Clinic Proceedings·Martijn B KatanUNKNOWN Stresa Workshop Participants
Feb 11, 2004·Circulation·G SalenUNKNOWN Multicenter Sitosterolemia Study Group
Feb 21, 2004·Science·Scott W AltmannMichael P Graziano

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Citations

Jul 4, 2012·The Journal of Clinical Investigation·Alanna StrongDaniel J Rader
Aug 20, 2010·Diabetology & Metabolic Syndrome·Alfredo HalpernMarcia Nery
Aug 4, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K A AminA H Abd Elsttar
Apr 1, 2006·Current Medical Research and Opinion·Stella S Daskalopoulou, Dimitri P Mikhailidis
Oct 23, 2016·Wiener medizinische Wochenschrift·Raimund WeitgasserPeter Siostrzonek
Mar 14, 2007·Journal of Pineal Research·Saad Abdul-Rehman Hussain
Apr 25, 2006·Journal of Internal Medicine·S Marcovina, C J Packard
Aug 11, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vladimir SavranskyVsevolod Y Polotsky
Aug 8, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Javier Antunez-SolisCarlos Wong
Jan 31, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·François LeblondEmile Levy
May 21, 2020·Disease Models & Mechanisms·Rebecca A AndersonJacek Topczewski

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