PMID: 15228212Jul 2, 2004Paper

Cholesterol metabolism in rat is affected by protocatechuic acid

Journal of Nutritional Science and Vitaminology
Akiko TamuraObihiro, Hokkaido 080-8555, Japan

Abstract

The effects of protocatechuic acid on serum cholesterol and gene expression related to cholesterol metabolism in rats were investigated. Rats were fed a cholesterol-free diet with or without 5 g protocatechuic acid/kg diet for 4 wk. There were no significant differences in body weight and food intake among groups through the experimental period. The liver weight in the protocatechuic acid group was significantly lower than that in the control group. The serum total cholesterol, high-density lipoprotein (HDL)-cholesterol and very low-density lipoprotein (VLDL)+intermediate density lipoprotein (IDL)+low-density lipoprotein (LDL)-cholesterol concentrations in the protocatechuic acid group were significantly lower than those in the control group through the feeding period. The hepatic cholesterol concentration in the protocatechuic acid group was significantly higher than in the control group at the end of the 4-wk feeding period. The relative hepatic LDL receptor, apo B, apo E, lecithin-cholesterol acyltransferase (LCAT) and hepatic triglyceride lipase (HTGL) mRNA levels in the protocatechuic acid group were significantly higher than those in the control group. The results of this study suggest the possibility that the increase in...Continue Reading

Citations

Jul 11, 2008·Bioresource Technology·Raúl Marín-MartinezRamón G Guevara-Gonzalez
Jul 19, 2011·Journal of Ethnopharmacology·S YagiD Laurain-Mattar
Oct 20, 2010·The British Journal of Nutrition·Gary Williamson, Michael N Clifford

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