Cholesterol metabolism: New functions and therapeutic approaches in cancer

Biochimica Et Biophysica Acta. Reviews on Cancer
Huanji XuFeng Bi

Abstract

Cholesterol and its metabolites (precursors and derivatives) play an important role in cancer. In recent years, numerous studies have reported the functions of cholesterol metabolism in the regulation of tumor biological processes, especially oncogenic signaling pathways, ferroptosis, and tumor microenvironment. Preclinical studies have over the years indicated the inhibitory effects of blocking cholesterol synthesis and uptake on tumor formation and growth. Besides, some new cholesterol metabolic molecules such as SOAT1, SQLE, and NPC1 have recently emerged as promising drug targets for cancer treatment. Here, we systematically review the roles of cholesterol and its metabolites, and the latest advances in cancer therapy targeting cholesterol metabolism.

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Citations

Nov 10, 2020·The International Journal of Biochemistry & Cell Biology·Joanna KopeckaChiara Riganti
Feb 13, 2021·Oxidative Medicine and Cellular Longevity·Yue ChengXiaojing Liu
Apr 2, 2021·Frontiers in Cell and Developmental Biology·Fan YangWenjing Du
Jun 11, 2021·Frontiers in Oncology·Isabella GiacominiVeronica Cocetta
Aug 31, 2021·Irish Journal of Medical Science·Xin-Chun WangLi-Feng Feng

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