PMID: 335969Oct 1, 1977

Cholesterol-reducing bacterium from human feces

Applied and Environmental Microbiology
M R SadzikowskiT D Wilkins


An anaerobic, gram-positive diplobacillus that reduces cholesterol to coprostanol was isolated from human feces and rat cecal contents. The isolates closely resemble a cholesterol-reducing organism isolated by Eyssen et al. (H. Eyssen et al., Eur. J. Biochem. 36:412-421, 1973) from a rat's cecum. These organisms would not form colonies and were isolated and cultivated in an anaerobic medium containing homogenized pork brains (naturally high in cholesterol). These organisms require free or esterified cholesterol for growth. They were isolated by serially diluting feces or cecal contents and inoculating brain medium. Colony-forming organisms, which did not reduce cholesterol, were eliminated by addition of inhibitory agents to the brain medium cultures. This serial dilution procedure was performed until a pure culture of a cholesterol-reducing organism was obtained.


Dec 1, 1992·Scandinavian Journal of Gastroenterology·G Márquez-Ruiz, M C Dobarganes
Feb 1, 1986·European Journal of Clinical Investigation·T MidtvedtM Steinbakk
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Mar 1, 1995·Letters in Applied Microbiology·L LiD C Beitz
Jun 19, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·E CollinderT Midtvedt
Jan 12, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Weiqing TangLiqing Yu
Jan 15, 2017·Molecular Nutrition & Food Research·Rima H MistryUwe J F Tietge
Sep 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T MidtvedtK E Norin
Dec 1, 1988·Biomedical & Environmental Mass Spectrometry·L C HudginsF H Field
Jun 3, 2000·Equine Veterinary Journal·E CollinderE Norin
Feb 20, 2007·The Journal of Biological Chemistry·Yin-Ru ChiangGeorg Fuchs
Sep 1, 1993·Scandinavian Journal of Gastroenterology·P BennoT Midtvedt
Apr 20, 2005·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·M E CardonaE Norin
Feb 1, 1990·Annals of Medicine·A H Lichtenstein
Jan 1, 1985·Critical Reviews in Toxicology·I R RowlandA Wise
Jan 1, 1991·Critical Reviews in Microbiology·R I MackieM P Bryant
Jun 11, 2002·Annual Review of Nutrition·Lora V HooperJeffrey I Gordon
Jan 1, 1988·Scandinavian Journal of Gastroenterology·C E LeijonmarckT Midtvedt

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