PMID: 8610922May 15, 1996Paper

Cholesterol reduction: weighing the benefits and risks

Annals of Internal Medicine
J M GazianoC H Hennekens

Abstract

The National Cholesterol Education Program recommends reducing total and low-density lipoprotein cholesterol levels to decrease the risk for coronary heart disease. The available evidence clearly indicates that higher cholesterol levels increase the risk for coronary heart disease and that cholesterol reduction results in corresponding decreases in risk. In contrast, existing data do not strongly support the idea that cholesterol reduction causes increases in any specific nonvascular cause of death. The outcomes of ongoing, large-scale trials will enable existing guidelines to be refined. However, current recommendations, which encourage nonpharmacologic interventions for about 30% of U.S. adults and cholesterol-reducing drugs for about 7% of U.S. adults, seem both justified and warranted.

Citations

Mar 14, 2007·Journal of the American College of Nutrition·Michael A PellizzonDaniel J Rader
Sep 28, 2001·Current Opinion in Cardiology·C J VaughanC T Basson
Jan 13, 2000·Journal of General Internal Medicine·S R MajumdarS B Soumerai
Sep 12, 2000·Current Cardiology Reports·J M Gaziano
Nov 4, 2000·Expert Opinion on Investigational Drugs·M H DavidsonR M Kleinpell
Jul 10, 2002·Stroke; a Journal of Cerebral Circulation·Richard B HorensteinLori Mosca

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