Abstract
Biliary proteins are promoters of cholesterol crystallization in artificial model bile. However, their pathogenic importance for cholesterol precipitation in native gallbladder bile (GB) is uncertain. The aim of this study was to evaluate the significance of biliary lipids and proteins on cholesterol crystal detection time (ChCDT) of GB in patients with gallstones. ChCDT and concentrations of lipids, albumin, mucins, aminopeptidase N, alpha1-acid glycoprotein, haptoglobin, and immunoglobulins (Igs) were measured in GB of 92 patients, 52 of whom had cholesterol gallstones. ChCDT was markedly reduced in gallstone patients. Compared with patients without gallstones, they had a significant increase in cholesterol saturation and total protein, albumin, mucin, and IgG biliary concentrations. In univariate analysis, ChCDT of GB was significantly correlated with cholesterol saturation and total lipid, protein, Ig, aminopeptidase N, and alpha1-acid glycoprotein concentrations. However, stepwise logistic regression analysis showed that only cholesterol saturation independently correlated to ChCDT. Gallbladder inflammation correlated with the concentration of Igs, but subtraction of IgG from GB did not modify the ChCDT. Biliary cholestero...Continue Reading
References
Aug 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L GuesdonS Avrameas
Nov 2, 1991·Lancet·G Paumgartner, T Sauerbruch
Oct 15, 1991·Biochimica Et Biophysica Acta·K ChijiiwaF Nakayama
Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K J van ErpecumF L Willekens
Apr 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A K GroenG N Tytgat
Aug 15, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·P R HarveyS M Strasberg
Apr 1, 1988·Gut·S N Marcus, K W Heaton
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A K GroenG N Tytgat
Sep 25, 1987·Biochimica Et Biophysica Acta·P R HarveyS M Strasberg
Aug 3, 1984·Science·A KibeS J Mao
Jan 1, 1984·The Journal of Clinical Investigation·R T HolzbachR E Hermann
Jun 1, 1981·The Journal of Clinical Investigation·S P LeeM C Carey
Sep 12, 1980·Journal of Chromatography·G Mingrone, A V Greco
Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S H HussainiR H Dowling
Nov 1, 1995·Gastroenterology·N H AfdhalG D Offner
Sep 1, 1995·Gut·L NúñezJ Garrido
Jun 1, 1995·Digestive Diseases and Sciences·H NuutinenR T Holzbach
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J R SanabriaS M Strasberg
Sep 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A de BruijnA K Groen
Aug 23, 1993·FEBS Letters·L NúñezF Nervi
Jan 1, 1993·Gut·Z HalpernT Gilat
Feb 22, 1993·FEBS Letters·J F MiquelF Nervi
Apr 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N H AfdhalG D Offner
Dec 1, 1995·The Journal of Clinical Investigation·N BuschS Matern
May 1, 1996·European Journal of Clinical Investigation·M D Apstein, M C Carey
Citations
Nov 15, 2006·Wiener medizinische Wochenschrift·Gottfried Novacek
Jun 12, 2004·Current Gastroenterology Reports·David Q-H Wang, Nezam H Afdhal
Oct 30, 2001·Journal of Hepatology·K J van ErpecumM C Carey
Apr 13, 1999·Gastroenterology Clinics of North America·J M Donovan
Oct 7, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Cynthia W KoSum P Lee
May 16, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P PortincasaG Palasciano
Dec 21, 2000·European Journal of Clinical Investigation·U GustafssonC Einarsson
Oct 7, 2006·Current Opinion in Gastroenterology·W A Hoogerwerf, R D Soloway
Dec 2, 2011·Journal of Lipids·Mary Carmen VázquezSilvana Zanlungo
Jan 26, 2013·PloS One·Diancai ZhangDuan Cai
Mar 1, 2011·Clinics and Research in Hepatology and Gastroenterology·Karel Johannes Van Erpecum
May 19, 2010·Gastroenterology Clinics of North America·Niels Gerard Venneman, Karel Johannes van Erpecum
Dec 27, 2008·Gastroenterology·Kirk J MaurerJames G Fox
Oct 20, 2005·Biology of the Cell·Karel J van Erpecum
Jun 6, 2007·Journal of Internal Medicine·H-U Marschall, C Einarsson
Aug 18, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Oliver von KampenJochen Hampe
Sep 30, 2004·The Journal of Laboratory and Clinical Medicine·Dieter JüngstSven Fischer
Mar 7, 2006·Biochemical and Biophysical Research Communications·Jin WangGösta Eggertsen
Sep 30, 1998·Gastroenterology·J F MiquelF Nervi
Apr 28, 2000·Gastroenterology·S G CorradiniA F Attili
Apr 12, 2000·The American Journal of Medicine·M M MamdaniC D Naylor
Dec 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andrés KleinSilvana Zanlungo
Mar 1, 2008·Journal of Hepatology·Frank Lammert, Juan-Francisco Miquel
Jan 23, 2016·PloS One·Jian WuZhao-Yan Jiang
Mar 27, 2007·Journal of Lipid Research·Juan G MellaJuan Francisco Miquel
Jul 23, 2003·The American Journal of Gastroenterology·Kiyoshi HasegawaMasatoshi Makuuchi
Sep 17, 2004·Fetal and Pediatric Pathology·M Carolina Wallis-Crespo, Antonio Crespo
Jan 6, 2019·Journal of Lipid Research·Mats RudlingSara Straniero
May 6, 2020·Scientific Reports·Eleodoro RiverasJuan F Miquel
Jan 31, 2002·World Journal of Gastroenterology : WJG·F LammertS Matern
Jul 11, 2003·World Journal of Gastroenterology : WJG·Ulf GustafssonCurt Einarsson
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Yining WangJunbo Hong