PMID: 2097343Jan 1, 1990Paper

Cholesterol side-chain cleavage activity in the human umbilical cord in vitro

Journal of Perinatal Medicine
R GunasegaramS Shanmugaratnam

Abstract

With a view to establish whether cells of the human umbilical cord possess cholesterol side-chain cleavage activity, homogenates of term umbilical cord obtained following spontaneous vaginal delivery from uncomplicated pregnancies (n = 6; 38-40 weeks gestation) were incubated with 26-14C cholesterol. Controls were homogenates heating in a boiling water bath for 10 min. Proof of the existence of cholesterol C-20, 22-desmolase activity in the viable tissue was established by associating radioactivity due to the labelled carbon 26 of 26-14C cholesterol with the p-bromophenacyl ester of isocaproic acid by reverse-isotope dilution analysis. The desmolase efficiency expressed as specific activity of 14C isocaproic acid, dpm g-1 tissue varied from 110 to 351 with a mean of 202. The small but definite conversion indicates that the cholesterol side-chain cleavage reaction previously believed to be exclusive to the steroidogenic pathway operating in the adrenal, gonads and placenta does exist in the human term umbilical cord in vitro.

References

Jan 1, 1969·Vitamins and Hormones·S I Sulimovici, G S Boyd
Jan 1, 1981·Annual Review of Physiology·E R Simpson, P C MacDonald

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