Cholesterol, the central lipid of mammalian cells.

Current Opinion in Cell Biology
F R Maxfield, Gerrit van Meer

Abstract

Despite its importance for mammalian cell biology and human health, there are many basic aspects of cholesterol homeostasis that are not well understood. Even for the well-characterized delivery of cholesterol to cells via lipoproteins, a novel regulatory mechanism has been discovered recently, involving a serum protein called PCSK9, which profoundly affects lipoproteins and their receptors. Cells can export cholesterol by processes that require the activity of ABC transporters, but the molecular mechanisms for cholesterol transport remain unclear. Cholesterol levels in different organelles vary by 5-10-fold, and the mechanisms for maintaining these differences are now partially understood. Several proteins have been proposed to play a role in the inter-organelle movement of cholesterol, but many aspects of the mechanisms for regulating intracellular transport and distribution of cholesterol remain to be worked out. The endoplasmic reticulum is the main organelle responsible for regulation of cholesterol synthesis, and careful measurements have shown that the proteins responsible for sterol sensing respond over a very narrow range of cholesterol concentrations to provide very precise, switch-like control over cholesterol synthe...Continue Reading

References

Nov 1, 1989·The Journal of Cell Biology·M P LisantiE Rodriguez-Boulan
Jan 1, 1988·Journal of Cellular Biochemistry·G van Meer, K Simons
Mar 24, 1999·The Journal of Cell Biology·S MukherjeeF R Maxfield
May 10, 2000·Nature Structural Biology·Y Tsujishita, J H Hurley
Sep 25, 2003·The Journal of Biological Chemistry·Gregory A GrafHelen H Hobbs
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nobutaka OhgamiTa-Yuan Chang
Oct 7, 2004·Biochimica Et Biophysica Acta·Stephen L SturleyLaura Liscum
Dec 15, 2004·The Journal of Biological Chemistry·Keigo KumagaiKentaro Hanada
Mar 5, 2005·Science·Ping-Yuan WangRichard G W Anderson
Apr 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·A T HammondG W Feigenson
Jun 25, 2005·Journal of Cell Science·Fabien Alpy, Catherine Tomasetto
Jul 27, 2005·Biochimica Et Biophysica Acta·Sarah L Veatch, Sarah L Keller
Aug 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Arun Radhakrishnan, Harden McConnell
Jun 1, 2007·The Journal of Biological Chemistry·Markey C McNuttJay D Horton
Jun 19, 2007·The Journal of Biological Chemistry·Sujuan XuAnn M Stock
Jul 5, 2007·The Biochemical Journal·Jun LiJennifer L Harris
Nov 9, 2007·The Journal of Biological Chemistry·Rodney E InfanteMichael S Brown
Nov 9, 2007·The Journal of Biological Chemistry·Rodney E InfanteJoseph L Goldstein
Jan 17, 2008·Biochemistry·Daping FanSergio Fazio
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Gerrit van MeerGerald W Feigenson
Apr 12, 2008·Journal of Lipid Research·Daniel Rodriguez-AgudoWilliam M Pandak
Apr 22, 2008·Progress in Lipid Research·Yvonne Lange, Theodore L Steck
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Da-Wei ZhangHelen H Hobbs
Sep 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rodney E InfanteJoseph L Goldstein
Sep 11, 2008·BMC Evolutionary Biology·Shiri FreilichJanet M Thornton
Sep 23, 2008·Biochimica Et Biophysica Acta·Gerald W Feigenson
Oct 1, 2008·Biochemistry·Zhi XuJudith Storch
Nov 21, 2008·Journal of Lipid Research·Jay D HortonHelen H Hobbs
Mar 11, 2009·Biochimica Et Biophysica Acta·Harry R Davis, Scott W Altmann
Mar 17, 2009·Biochimica Et Biophysica Acta·Bruno Mesmin, Frederick R Maxfield
Mar 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Benoit SorrePatricia Bassereau
Apr 8, 2009·Biophysical Journal·A Tian, T Baumgart

❮ Previous
Next ❯

Citations

Aug 8, 2012·The Journal of Biological Chemistry·Ika KristianaAndrew J Brown
Feb 16, 2012·The Journal of Biological Chemistry·Christopher T BehAnant K Menon
Aug 20, 2012·Journal of Diabetes Investigation·Ronald Dirkx, Michele Solimena
Jan 25, 2013·International Journal of Breast Cancer·Breonna J Martin, Kenneth L van Golen
Aug 25, 2011·Journal of Lipid Research·Reiko IshitsukaToshihide Kobayashi
Oct 4, 2011·The Journal of Endocrinology·Barbara J Clark
Sep 9, 2011·Molecular Biology of the Cell·Bruno MesminFrederick R Maxfield
Sep 3, 2014·The Journal of Cell Biology·Josse van GalenVivek Malhotra
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Klaus-Armin Nave, Hauke B Werner
Sep 5, 2013·Trends in Cell Biology·Takashi TatsutaThomas Langer
Jan 4, 2013·Cellular and Molecular Life Sciences : CMLS·Bruno MesminGuillaume Drin
Nov 8, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vesa M Olkkonen
Feb 14, 2016·Chemistry and Physics of Lipids·Yvonne Lange, Theodore L Steck
Nov 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jian LiSuzanne R Pfeffer
Nov 12, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takeshi YamamuraToyoshi Fujimoto
Jun 15, 2012·Current Opinion in Cell Biology·Sumana RaychaudhuriChristopher Loewen
Mar 10, 2012·Advanced Drug Delivery Reviews·David Hymel, Blake R Peterson
Jan 7, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Vesa M OlkkonenElina Ikonen
Jul 15, 2015·Biochemistry·David B IaeaFrederick R Maxfield
Mar 2, 2016·Biochimica Et Biophysica Acta·Bruno Mesmin, Bruno Antonny
Mar 20, 2016·Chemistry and Physics of Lipids·Vicky HoweAndrew J Brown
Jun 21, 2014·Protein Science : a Publication of the Protein Society·Irina D PogozhevaAndrei L Lomize
Dec 18, 2013·Traffic·Emmanuelle GirardChristophe Lamaze
Nov 30, 2013·Molecular Nutrition & Food Research·Alberto Canfrán-DuqueRebeca Busto
Jul 3, 2013·Biochimica Et Biophysica Acta·Irina D PogozhevaAndrei L Lomize
Mar 19, 2014·Journal of the American College of Cardiology·Allan D SnidermanSergio Fazio
Apr 22, 2014·Cell Reports·Meritxell ReverterCarlos Enrich
Feb 25, 2014·Molecular Aspects of Medicine·Albert K GroenFolkert Kuipers
Nov 19, 2014·Current Atherosclerosis Reports·David I FeldmanSeth S Martin

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.