PMID: 9194753Jun 1, 1997Paper

Cholesteryl ester transfer protein activity enhances plasma cholesteryl ester formation. Studies in CETP transgenic mice and human genetic CETP deficiency

Arteriosclerosis, Thrombosis, and Vascular Biology
H C OliveiraA R Tall

Abstract

The plasma cholesteryl ester transfer protein (CETP) promotes the removal of HDL cholesteryl esters and is thought to stimulate reverse cholesterol transport (RCT). However, mechanisms by which CETP may stimulate RCT are poorly understood. Thus, we examined the relationship between plasma CETP expression and plasma cholesteryl ester formation in CETP transgenic (Tg) mice, hamsters, and human subjects with genetic CETP deficiency. Incubation of CETP Tg mouse plasma showed a 20% to 40% increase in plasma cholesterol esterification rate (CER, P < .05) compared with control mice. Injection of a neutralizing CETP monoclonal antibody (MAb) (TP2) into natural flanking region CETP Tg mice resulted in an increase in plasma free cholesterol (FC) concentration, FC/CE ratio, FC/phosphatidylcholine ratio, and hepatic CETP mRNA. In hamsters, CETP inhibition also resulted in an increase in plasma FC/phosphatidylcholine ratio and increased CETP mRNA in adipose tissue. In humans with two common CETP gene mutations (an intron 14 splicing defect and a D442G missense mutation), mean plasma CERs were 39 and 60, respectively, compared with 89 nmol x mL-1 x h-1 in normal subjects. By contrast, lecithin:cholesterol acyltransferase (LCAT) mass was norm...Continue Reading

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Citations

Sep 17, 1999·Atherosclerosis·K A RyeP J Barter
Apr 8, 1999·Progress in Lipid Research·A Jonas
Sep 11, 1999·Current Opinion in Lipidology·L L Rudel, A A Kesäniemi
Aug 17, 2000·Current Opinion in Lipidology·A InazuH Mabuchi
Mar 27, 2001·Current Opinion in Lipidology·E FayardJ Auwerx
Feb 10, 2004·Cardiology in Review·Christine E YoungJeffrey T Kuvin
May 9, 2012·Journal of Lipid Research·Sandra Kunnen, Miranda Van Eck
Jun 19, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Kan SatoYukio Akiba
Jan 13, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kenji MiwaMasakazu Yamagishi
Feb 3, 2007·Journal of Lipid Research·Ji-Young LeeJohn S Parks
Jan 9, 2003·Journal of Lipid Research·Patrícia M CazitaHelena C F Oliveira
Mar 1, 2018·Journal of Lipid Research·Sudichhya ShresthaKerry-Anne Rye
Apr 12, 2003·Molecular Endocrinology·Peter Tontonoz, David J Mangelsdorf
Jul 17, 2004·Journal of Atherosclerosis and Thrombosis·Makoto NaganoYuji Matsuzawa
Jan 19, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Alexander D DergunovGennady E Dobretsov

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